Inositol Phosphates

Inositol phosphates are important intracellular second messengers in eukaryotic cells. Inositol, a cyclic molecule with six hydroxyl groups, forms the hydrophobic head group of membrane inositol phospholipids. The actions of lipid kinases and phosphatases on the inositol ring of inositol phospholipids generate a variety of phosphoinositol phospholipids. As a result of upstream signaling events, specific phospholipases are activated, cleave phosphoinositol phospholipids, and release intracellular inositol phosphate second messenger molecules.
The most studied inositol phosphate second messenger is inositol 1,4,5-trisphosphate (IP3). IP3 is released from phosphatidylinositol 4,5-bisphosphate (PIP2) by the action of phospholipase C-β and is responsible for the release of calcium ions from intracellular stores in the endoplasmic reticulum.

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P6990 1,2-Dipalmitoylphosphatidylinositol 3,4-diphosphate sodium salt ≥98%, solid
    • P7115 1,2-Dipalmitoylphosphatidylinositol 4,5-diphosphate triammonium salt ≥98%, solid
    • P4240 1,2-Dipalmitoylphosphatidylinositol 3,4,5-trisphosphate tetrasodium salt ≥98%
    • I5125 myo-Inositol ≥99%
    • I7508 myo-Inositol BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture
    • I8132 scyllo-Inositol ≥98%
    • I0510 D-myo-Inositol 1,4-bisphosphate potassium salt from bovine brain, ≥98% (TLC)
    • I3264 D-myo-Inositol 4,5-bisphosphate ammonium salt
    • I9261 myo-Inositol 1,3,4,5,6-pentakisphosphate ammonium salt ≥95%
    • I8636 D-myo-Inositol 1,3,4,5-tetrakis(phosphate) ammonium salt ≥95%
    • I0143 D-myo-Inositol 1,3,4,5-tetrakis(phosphate) potassium salt
    • I131 D-myo-Inositol 1,3,4,5-tetrakis(phosphate) potassium salt
    • I9766 D-myo-Inositol 1,4,5-tris-phosphate trisodium salt
    • I7012 D-myo-Inositol 1,4,5-trisphosphate potassium salt synthetic
    • L9908 LY-294,002 hydrochloride solid, ≥98% (HPLC)
    • P1652 D-α-Phosphatidylcholine, dipalmitoyl ≥99%
    • P1368 L-α-Phosphatidylinositol dipalmitoyl ammonium salt ≥98% (TLC)
    • P9763 L-α-Phosphatidylinositol 4,5-diphosphate sodium salt from bovine brain ≥98% (TLC)
    • P4725 L-α-Phosphatidyl-D-myo-inositol 3,4-diphosphate, dioctanoyl
    • P3584 L-α-Phosphatidyl-D-myo-inositol 4,5-diphosphate, dioctanoyl
    • P5713 L-α-Phosphatidyl-D-myo-inositol 3,5-diphosphate, dipalmitoyl
    • P9638 L-α-Phosphatidylinositol 4-monophosphate sodium salt ≥98%
    • P5578 L-α-Phosphatidyl-D-myo-inositol 3-monophosphate, dioctanoyl
    • P3953 L-α-Phosphatidyl-D-myo-inositol 3-monophosphate, dipalmitoyl
    • P7686 L-α-Phosphatidyl-D-myo-inositol 4-monophosphate, dipalmitoyl ammonium salt
    • P1168 L-α-Phosphatidyl-D-myo-inositol 5-monophosphate, dipalmitoyl
    • P9953 L-α-Phosphatidyl-D-myo-inositol 3,4,5-triphosphate, dioctanoyl
    • P8615 Phosphoinositide 3-kinase p110γ human ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution
    • P6023 Phosphoinositides sodium salt from bovine brain
    • SRP4838 PTEN human recombinant, expressed in E. coli
    • Q4951 Quercetin ≥95% (HPLC), solid
    • W1628 Wortmannin from Penicillium funiculosum, ≥98% (HPLC and TLC)
    • W3144 Wortmannin, Ready Made Solution from Penicillium funiculosum, ≥95% (HPLC)