Cholesterol and Cholesterol Metabolism

Cholesterol is an organic compound that is categorized as a waxy steroid of fat. It is a structural component of animal cell membranes and a key factor in membrane permeability. In animal cells, cholesterol supports intracellular transport, cell signaling, and nerve conduction. In addition, cholesterol is converted to bile acids, steroid hormones, and vitamin D. It is formed (from Acetyl CoA) and stored in the liver, where it is oxidized into bile acids, which are then stored in the gallbladder. Essential for the digestion and absorption of dietary fats, about 95% of the bile acids are reabsorbed from the intestines.

Cholesterol is found in many foods, and the body adjusts for cholesterol intake by adjusting the amount that is synthesized. The levels of cholesterol must be regulated in order to prevent over-accumulation and abnormal deposition in the body, resulting in atherosclerosis and cardiovascular disease.

Sigma-Aldrich has a variety of products for the investigation of cholesterol metabolism.

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SML1837 K-604 ≥98% (HPLC)
SRP4326 Apo-D human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
SRP4695 ApoA-1 from rat recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
SRP4760 ApoE2 human recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)
SRP4696 ApoE3 human recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)
A0722 Apolipoprotein A-I from human plasma ≥85% (SDS-PAGE), buffered aqueous solution
A7785 Apolipoprotein C-I from human plasma ≥95% (SDS-PAGE), lyophilized powder
SRP4693 Apolipoprotein A−I human recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
A3234 Apolipoprotein E4 human recombinant, expressed in E. coli, ≥90% (SDS-PAGE and HPLC), lyophilized powder
A0972 Apolipoprotein A-II from human plasma ≥95% (SDS-PAGE), buffered aqueous solution
A7910 Apolipoprotein C-II from human plasma ≥95% (SDS-PAGE)
SRP4324 Apo-SAA human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
A9861 Auraptene ≥98% (HPLC)
PZ0190 Avasimibe ≥98% (HPLC)
SML0059 BLT-1 ≥98% (HPLC)
SML0512 BLT-4 ≥98% (HPLC)
SML0784 BMS-303141 ≥98% (HPLC)
SML0005 Cerivastatin sodium salt hydrate ≥98% (HPLC)
SML0447 3-Chloro-5-hydroxybenzoic acid ≥97% (HPLC)
C8128 5α-Cholestan-3-one crystalline
C8667 Cholesterol Sigma Grade, ≥99%
C8503 Cholesterol from sheep wool, ≥92.5% (GC), powder
C3292 Cholesterol ≥95% (GC), powder, Ash, free
C1235 Cholesterol Oxidase microbial recombinant, expressed in E. coli, lyophilized powder, ≥50 units/mg protein
C1145 Cholesterol–PEG 600
C8048 Cholesterylaniline 99%
C0879 i-Cholesteryl methyl ether ~95%
C2205 Cholesteryl (pyren-1-yl)hexanoate ≥98%
C3743 CI 976 >98% (HPLC), solid
C6643 Clofibrate liquid
C8624 COG 133 trifluoroacetate salt ≥95% (HPLC)
C2005 Coprostane
PZ0103 CP-346086 dihydrate ≥97% (HPLC)
PZ0226 CP 524515 ≥98% (HPLC)
PZ0225 CP 532623 ≥98% (HPLC)
SML0541 7α,25-Dihydroxycholesterol ≥98% (HPLC)
E2634 Ergosta-5,7,9(11),22-tetraen-3β-ol ~96% (HPLC)
F6020 Fenofibrate ≥99%, powder
F2929 6-Fluoromevalonate ≥90% (GC), viscous liquid
G9518 Gemfibrozil
G5168 (Z)-Guggulsterone ≥89% (HPLC), powder
G4923 (E)-Guggulsterone ≥95% (HPLC), powder
SML1648 24(S)-Hydroxycholesterol ≥98% (HPLC)
SML0301 Hymeglusin ≥98% (HPLC), from Fusarium sp.
I8255 19-Iodocholesterol 3-acetate ~95% (TLC)
L5768 Lanosterol ≥93%, powder
L8016 Anti-β-Lipoprotein (LDL) antibody produced in goat whole antiserum
SML1385 Lomitapide ≥98% (HPLC)
SML0441 LUF6283 ≥95% (HPLC)
M2537 Mevastatin ≥95% (HPLC), powder
SML1885 Mitotane ≥98% (HPLC)
SML0831 ML261 ≥98% (HPLC)
SML1604 NDB ≥98% (HPLC)
SML0777 Oltipraz metabolite M2 ≥98% (HPLC)
SML1132 Pep2-8 trifluoroacetate salt ≥95% (HPLC), contains 58μL of solution at 10mM in DMSO
PZ0222 PF-04445597 ≥98% (HPLC)
PZ0207 PF-04620110 ≥98% (HPLC)
PZ0299 PF-05175157 ≥98% (HPLC)
PZ0233 PF-06424439 ≥98% (HPLC)
SML0682 PluriSIn #1 ≥95% (HPLC)
SML0639 Ro 11-1464 ≥98% (HPLC)
SML1264 Rosuvastatin calcium ≥98% (HPLC)
S6445 S-2E ≥98% (HPLC), powder
S9318 Sandoz 58-035 >98% (HPLC), powder
SML1712 SBC-115076 ≥98% (HPLC)
S1270 β-Sitosterol synthetic, ≥95%
S9889 β-Sitosterol from soybean, ≥96%
S4194 SR 12813 ≥98%, solid
SML1513 SR1848 ≥98% (HPLC)
SML0539 T863 ≥98% (HPLC)
SML1758 Tetrazanbigen ≥98% (HPLC)
SML1626 TFCA ≥98% (HPLC)
PZ0170 Torcetrapib ≥98% (HPLC)
T4540 Triacsin C from Streptomyces sp.
U3633 U 18666A powder
PZ0257 WAY-252623 ≥98% (HPLC)
PZ0267 WAY-362450 ≥98% (HPLC)
SML1324 XEN445 ≥98% (HPLC)
Z2626 Zaragozic acid A trisodium salt ≥95% (HPLC), microbial