Phospholipases

Phosphatidic Acid Synthesis
The endoplasmic reticulum (ER) produces most of the lipids required for the generation of new cell membranes. These lipids include cholesterol as well as the phospholipids phosphatidylcholine (PC) and phosphatidic acid (PA). PA is produced by the cleavage of PC to generate PA by the enzyme phospholipase D1 (PLD1). PLD1 is activated by various ligands (agonists) via G-protein-coupled receptors (GPCRs) or receptor tyrosine kinases (RTKs) and is mediated by protein kinase C (PKC) as well as by the small GTPbinding proteins Rho (RhoA, Rac1 and Cdc42) and ADP-ribosylation factor1 (ARF1).
References:
1. Exton, J.H., Phospholipase D. Ann. N.Y. Acad. Sci., 905, 61-68 (2000).
2. McPhail, L.C., et al., A novel protein kinase target for the lipid second messenger phosphatidic acid. Biochim. Biophys. Acta, 1439, 277-290 (1999).
3. Daniel, L.W., et al., Phospholipase D, tumor promoters, proliferation and prostaglandins. Biochim. Biophys. Acta, 1439, 265-276 (1999).

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P7778 Phospholipase A2 from Naja mossambica mossambica 3.1.1.4  ( BRENDA | IUBMB )
lyophilized powder
P8913 Phospholipase A2 from bovine pancreas 3.1.1.4  ( BRENDA | IUBMB )
lyophilized powder
P9279 Phospholipase A2 from honey bee venom (Apis mellifera) 3.1.1.4  ( BRENDA | IUBMB )
salt-free, lyophilized powder
P6534 Phospholipase A2 from porcine pancreas 3.1.1.4  ( BRENDA | IUBMB )
ammonium sulfate suspension
P4039 Phospholipase C from Clostridium perfringens (C. welchii) 3.1.4.3  ( BRENDA | IUBMB )
lyophilized powder
P5542 Phospholipase C, Phosphatidylinositol-specific from Bacillus cereus 4.6.1.13  ( BRENDA | IUBMB )
lyophilized powder
P0065 Phospholipase D from Streptomyces chromofuscus 3.1.4.4  ( BRENDA | IUBMB )
buffered aqueous glycerol solution