Certain features of will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Adenylyl Cyclase Inhibitors

Adenylyl Cyclase (or Adenylate Cyclase) is an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP). It therefore has diverse roles in cell regulation and activity. Adenylyl Cyclase is located in the plasma membrane, where it responds to the presence of hormones and chemical signals outside of the cell by triggering the conversion of ATP to cAMP. This cAMP is a secondary messenger, and an important component of signal transduction cascades within the cell, which subsequently activate other kinases to open ion channels or expose the active sites of other proteins. In neurons, calcium-sensitive Adenylyl Cyclases located next to calcium ion channels may play an important role in learning processes. Adenylyl Cyclase can be activated or inhibited by numerous agents, affecting the intracellular concentrations of cAMP. Sigma-Aldrich has numerous various agents that inhibit Adenylyl Cyclase, which in turn decreases intercellular cAMP levels and second messenger activity.

Product #


Add to Cart

C4479 9-Cyclopentyladenine monomethanesulfonate ≥98% (HPLC)
D7408 2′,5′-Dideoxyadenosine ≥95% (HPLC), solid
D0939 2′,5′-Dideoxyadenosine 3′-triphosphate tetrasodium salt >91% (HPLC)
K3394 KH7 ≥98% (HPLC)
SML1857 LRE1 ≥98% (HPLC)
M182 MDL-12,330A hydrochloride ≥98% (HPLC), powder
N2165 NKY80 ≥98% (HPLC)
SML0391 SB-268262 ≥98% (HPLC)
S153 SQ 22,536 ≥97% (HPLC), powder