Other Opioids

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SML0903   BMS-986124 ≥98% (HPLC) BMS-986124 is a silent allosteric modulator (SAM) of the m-opioid receptor (MOR). The compound BMS-986124 blocks the effects of the MOR positive allosteric modulator BMS-986122, but does not affect binding or activities of orthosteric MOR agonists such as endomorphin-I or DAMGO.
SML0016   CCG-63802 GCC-63802 binds to RGS4 and blocks interaction with Goa (IC50 = 1.9 uM). RGS4 (Regulator of G protein Signaling) is one of the RGP proteins responsible for terminating mu opioid receptor signaling. RSG proteins are GTPase activators, and drive G protein subunits to an inactive, GDP-bound form.
S1197   Sialorphin ≥98% (HPLC), powder Sialorphin is an analgesic and an exocrine and endocrine signaling mediator, predominantly synthesized in the submandibular gland and prostate of adult rats. Sialorphin prevents spinal and renal NEP from breaking down substance P and Met-enkephalin in vitro. It inhibits the breakdown of substance P with an IC50 of 0.4-1 μM and behaved as a competitive inhibitor; elicits potent antinociceptive responses in two behavioral rat models of injury-induced acute and tonic pain; and has a role in erectile function probably through a mechanism that involves relaxation of corporal smooth muscle tissue.
T2019 Thebaine powder The (-)-isomer of thebaine is the naturally-occurring constituent of opium that is a precursor of morphine. It has poor antinociceptive activity and induces convulsions. It binds to μ and δ opioid receptors in vitro.