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Anticonvulsants

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D4505 5,5-Diphenylhydantoin sodium salt ≥99% Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.
D4007 5,5-Diphenylhydantoin ≥99% Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.
E7138 Ethosuximide Used for the treatment of absence-type seizures
F0778 Felbamate Anticonvulsant agent that is an allosteric antagonist at the NR2B subunit of the NMDA glutamate receptor; also has γ-aminobutyric acid (GABAA) receptor agonist properties.
SML0117 Fosphenytoin disodium salt hydrate ≥98% (HPLC) Fosphenytoin is a water soluble phenytoin prodrug.
G154 Gabapentin solid Anticonvulsant with unknown mechanism of action; crosses the blood brain barrier; increases GABA concentrations in the brain and reduces excitatory amino acid neurotransmission, perhaps through its effects on voltage-gated calcium channels; exhibits antinociceptive, anxiolytic, neuroprotective and anti-epileptic effects.
SML0582   Hispidulin ≥98% (HPLC) Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand.
SML1082 Lamotrigine isethionate ≥98% (HPLC) Lamotrigine isethionate is an anticonvulsant, water soluble salt of Lamotrigine (Catalog No. L3791).
L3791 Lamotrigine ≥98%, powder Anticonvulsant.
L8668 Levetiracetam ≥98% (HPLC) Levetiracetam is a pyrrolidine with antiepileptic activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity.
A9345   N-(4-Amino-2-chlorophenyl)phthalimide Anticonvulsant
SML1592   Pimprinine ≥98% (HPLC) Pimprinine is an indole alkaloid extracted from Streptomyces species that exhibits anticonvulsant activity. Pimprinine is a potent MAO inhibitor. Also, Pimprinine effectively inhibits replication of enterovirus 71 (EV71) and adenovirus 7 (ADV-7).
PZ0010 Pregabalin ≥97% (NMR) Pregabalin is a lipophilic GABA analog/ligand at α2δ subunit of voltage-dependent Ca2+ channels. Pregabalin is an anticonvulsant, anxiolytic analgesic used to treat peripheral neuropathic pain and fibromyalgia.
R8404 Rufinamide ≥98% (HPLC), powder Broad-spectrum anticonvulsant.
P4543 Valproic acid sodium salt ≥98% Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.
V3640 Valpromide ≥97% (NMR) Valpromide (VPD) is a derivative of valproic acid (VPA) and is used as an antiepileptic drug. It is hydrolyzed quickly to VPA in vivo, but has intrinsic anticonvulsant activity.
Z2001 Zonisamide sodium salt ≥98% (HPLC), powder Zonisamide sodium salt is an anti-epileptic. It is effective in various animal epilepsy models and humans with both partial and generalized epileptic seizures. Zonisamide sodium salt also scavenges nitric oxide (NO).