The expression of multi-drug resistance (MDR) is key in the development of therapeutic and chemotherapeutic drugs. Accessibility, solubility, clearance rate, and drug-drug interactions can mean the difference between a wonder drug and a lethal drug. The classical form of MDR hinges on P-glycoprotein (Pgp) at the cell membrane. Pgp acts as a drug efflux pump, and provides a method to rid cells of both toxic and therapeutic compounds. Sigma has a comprehensive line of substrates, enzymes, antibodies and other screening reagents.
Drug metabolizing enzymes (DMEs) are a diverse group of proteins produced in the liver that are responsible for metabolizing a vast number of xenobiotic compounds. These compounds include exogenous proteins such as steroids, pharmaceuticals drugs, and environmental pollutants. Cytochrome P450 enzymes (CYPs) are known for their ability to metabolize a large number of structurally diverse compounds.