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A2218
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L-Ascorbic acid meets USP testing specifications
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Ascorbic Acid, also known as Vitamin C, is a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species.
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human ... SLC23A2(9962)
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A2385
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5-Azacytidine ≥98% (HPLC)
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A potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression, gene activation and silencing.
Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes.
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human ... DNMT1(1786), DNMT3A(1788), DNMT3B(1789)
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B1686
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BIO ≥98% (HPLC)
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6-bromoindirubin-3′-oxime (BIO) is a potent, reversible and ATP-competitive GSK-3α/β inhibitor and the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells. Human embryonic stem cells (hESCs) are maintained in the undifferentiated state through treatment with a GSK-3 inhibitor, BIO, under a feeder-free condition.
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B9311
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BIX 01294 trihydrochloride hydrate ≥98% (HPLC), powder
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BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro.1
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C4866
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Cardiogenol C hydrochloride ≥97% (HPLC), solid
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Cardiogenol C hydrochloride is a cardiomyogenesis inducer in embryonic stem cells.
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C4116
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Cyclopamine hydrate ≥98% (HPLC)
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Cyclopamine is a Hedgehog signaling pathway inhibitor; inhibits the growth of medulloblastoma cells.
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human ... EBP(10682)
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D1756
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Dexamethasone ≥98% (HPLC), powder
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Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
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human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)
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D0160
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16,16-Dimethylprostaglandin E2 methyl acetate solution
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SRP3258
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DKK-1 human recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE), ≥97% (HPLC), cell culture tested
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DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.
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human ... DKK1(22943)
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F6886
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Forskolin from Coleus forskohlii, ≥98% (HPLC), powder
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Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.1 Forskolin effects calcium currents and inhibits MAP kinase.
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human ... OPRK1(4986), SLC2A10(81031), TNF(7124)
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G3381
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Geldanamycin from Streptomyces hygroscopicus ≥98% (HPLC), powder
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Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
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SML0551
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Icaritin ≥98% (HPLC) 
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Icaritin is a component of Epimedium flavonoid isolated from Herba Epimedii, which enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs by inhibiting PPAR-g pathway. Icaritin has no effect on MSCs proliferation. Also, icaritin potently inhibits chronic myeloid leukemia (CML) and breast cancer cells proliferation most likely by modulation of MAPK/ERK/JNK and JAK2/STAT3 /AKT signaling. As other flavonoids, icaritin may exert estrogen-like activities.
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SML0370
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Kartogenin ≥98% (HPLC)
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Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.
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L9908
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LY-294,002 hydrochloride solid, ≥98% (HPLC)
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Specific cell permeable phosphatidylinositol 3-kinase inhibitor.
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R2625
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Retinoic acid ≥98% (HPLC), powder
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all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
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human ... RARA(5914), RARB(5915), RARG(5916), RXRA(6256), RXRB(6257), RXRG(6258)
mouse ... Rara(19401), Rarb(218772), Rarg(19411), Rxrb(20182)
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R3904
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Reversine ≥98% (HPLC), solid
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Reversine is a potent, selective human A3 adenosine receptor antagonist with a Ki value of 0.66 μM. Synthetic substituted purine implicated in cellular regeneration; induces differentiated myogenic-lineage-committed cells to become multipotent mesenchymal progenitor cells.
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human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora3(25370)
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T8552
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Trichostatin A ≥98% (HPLC), from Streptomyces sp.
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Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.
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human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869)
mouse ... ENSMUSG00000061062(15181)
rat ... Hdac7a(84582)
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Y0503
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Y-27632 dihydrochloride ≥98% (HPLC)
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Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.
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human ... ROCK1(6093), ROCK2(9475)
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