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Protein Kinase Inhibitors

A protein kinase is an enzyme that modifies proteins by transferring a phosphate group from ATP. This phosphorylation creates a phosphoprotein with altered protein activity, often acting as an on/off switch for protein functions. Protein kinases regulate cell functions like signal transduction, cell cycle, metabolism, differentiation, proliferation, and apoptosis. Protein kinases act on the amino acids serine, threonine, and tyrosine. A protein kinase inhibitor is a compound that blocks the action of one or more protein kinases.

Protein kinase dysfunction is connected to a wide variety of human diseases and conditions including cancer, inflammatory conditions, autoimmune disorders, and cardiac diseases. Protein kinase inhibitors are important research tools to study cell functions and human diseases. In some cases protein kinase inhibitors block cell proliferation, as in certain disease conditions. Sigma-Aldrich has a broad range of protein kinase inhibitors for use in the research of protein and cell functions.

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A2846 A-134974 dihydrochloride hydrate ≥98% (HPLC), solid
A4970 N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide
SML1110 Adaphostin ≥98% (HPLC) New
A6730 Akt1/2 kinase inhibitor ≥98% (HPLC)
A7410 Amiloride hydrochloride hydrate ≥98% (TLC), powder
A3230 AR-A014418 ≥98% (HPLC), solid
A4308 Autocamtide 2-related inhibitory peptide ≥97% (HPLC), lyophilized powder
B9685 BAY 61-3606 hydrochloride hydrate ≥98% (HPLC), powder
B3936 BAY R3401 ≥98% (HPLC), solid
B3686 BAY U6751 hydrate solid, ≥98% (HPLC)
B1686 BIO ≥98% (HPLC)
B3056 Bisindolylmaleimide II ≥97% (Mixture of 2 isomers)
B3306 Bisindolylmaleimide IV ≥98% (TLC), solid
B3681 Bisindolylmaleimide VII 96% (TLC), solid
B3931 Bisindolylmaleimide X hydrochloride ≥90%, solid
B4056 Bisindolylmaleimide XI hydrochloride ≥98% (TLC), solid
B7563 BRD7389 ≥98% (HPLC)
B178 Butein solid
C6303 Calphostin C from Cladosporium cladosporioides ≥90% (HPLC), powder
C9867 CGK733 ≥98% (HPLC), solid
C2932 Chelerythrine chloride ≥95% (TLC), powder
C3742 Chk2 Inhibitor II hydrate ≥98% (HPLC)
C0742 CKI-7 dihydrochloride ≥98% (HPLC), solid
SML0804 (S)-CPP sodium salt ≥96% (HPLC) New
C8863 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine ≥98% (HPLC)
D0817 (−)-Deguelin >98% (HPLC), powder
D3768 Dequalinium chloride hydrate ≥95% (titration)
D1916 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside
D2667 2,5-Dihydroxycinnamic acid methyl ester ≥95%, crystalline
D5564 7,8-Dihydroxycoumarin ≥97%, powder
P5499 Dorsomorphin ≥98% (HPLC)
E7881 Emodin from Frangula bark, ≥90% (HPLC)
G3381 Geldanamycin from Streptomyces hygroscopicus ≥98% (HPLC), powder
G6649 Genistein synthetic, ≥98% (HPLC), powder
G6776 Genistein from Glycine max (soybean), ~98% (HPLC)
G0897 Genistin from Glycine max (soybean), ≥95% (HPLC)
G2911 GF 109203X synthetic, ≥90% (HPLC)
B6292 GF 109203X hydrochloride ≥95%
G1918 Gö 6983 ≥97%
SML0660 GSK2578215A ≥98% (HPLC)
G0668 GW2974 ≥98% (HPLC), solid
G6416 GW5074 powder
I6891 H-7
I7016 H-7 dihydrochloride ≥98% (HPLC)
M9656 H-8 dihydrochloride >98% (HPLC)
B1427 H-89 dihydrochloride hydrate ≥98% (HPLC), powder
G1274 HA-1004 hydrochloride ≥98% (HPLC), powder
H6649 Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder
H5257 Hispidin solid, ≥98% (HPLC)
I0658 IC 261 ≥98% (HPLC)
05288 K-252a from Nocardiopsis sp.
K1639 K-252a from Nonomuraea longicatena, ≥98% (HPLC)
K2015 K-252a Ready Made Solution, from Nonomuraea longicatena, >98%
I2142 KN-62 ≥95%, powder
K1385 KN-93 ≥98% (HPLC)
K3761 KT 5720 ≥98% (HPLC), powder
K1388 KT 5823 ≥85% (HPLC), lyophilized powder
L1289 Lavendustin C ≥97%, solid
L6293 LY-364947 ≥98% (HPLC)
M7795 rac-2-Methoxy-3-hexadecanamido-1-propylphosphocholine ≥90%
M8045 rac-2-Methoxy-3-octadecanamido-1-propylphosphocholine >96% (TLC)
I2764 ML-7 powder
C1172 ML-9 ≥99% (TLC), powder
M8059 [Ala107]-Myelin Basic Protein Fragment 104-118
M8309 [Ala113]-Myelin Basic Protein Fragment 104-118 synthetic, lyophilized powder
M6760 Myricetin ≥96.0%, crystalline
N161 NPC-15437 dihydrochloride hydrate ≥98% (HPLC), solid
SML0185 NQDI-1 ≥98% (HPLC)
N9289 NVP-231 ≥98% (HPLC)
P4509 Palmitoyl-DL-carnitine chloride powder
P215 PD 98,059 solid
PZ0116 PD-166285 hydrate ≥98% (HPLC)
P0453 Piceatannol powder
P1004 Polymyxin B sulfate salt ≥6,000 USP units/mg
P6062 Protein Kinase A Inhibitor Fragment 6-22 amide ≥97% (HPLC)
P3115 Protein Kinase C Inhibitor, Myristoylated ≥7.5 mg/mL (peptide and counter ion), ≥95% (Minimum peptide content 70%, HPLC), aqueous solution (neutral pH)
P1614 Protein kinase Cζ pseudosubstrate, myristoyl trifluoroacetate salt ≥90% (HPLC)
P1864 Protein kinase Cη pseudosubstrate, myristoyl trifluoroacetate salt ≥90% (HPLC), lyophilized powder
P0393 Protein Kinase Inhibitor from porcine heart 1-3 inhibitor U/μg protein, lyophilized powder
P0300 Protein Kinase Inhibitor from rabbit ≥85% (HPLC)
P5015 Protein Kinase Inhibitor from rabbit muscle lyophilized powder, 0.2-1 inhibitor U/μg protein
P6624 PS-1145 dihydrochloride ≥98% (HPLC), solid
R2146 Radicicol from Diheterospora chlamydosporia solid
R136 Ro 31-8220 methanesulfonate salt solid
R137 Ro 31-0432 solid
R5648 Rottlerin ≥85%
S7067 SB 202190 ≥98% (HPLC)
S8307 SB 203580 solid, ≥98% (HPLC)
S3442 SB 216763 >98% (HPLC)
S9070 SB 220025 trihydrochloride ≥98% (HPLC), solid
S0569 SB 239063 >98% (HPLC)
S3567 SB 415286 ≥98% (HPLC)
S4696 SB-505124 hydrochloride hydrate ≥98% (HPLC)
SML0014 Scutellarin hydrate ≥98% (HPLC)
S0193 SKF-86002 ≥98% (HPLC), solid
S5696 SKI II ≥98% (HPLC), solid
S5567 SP600125 ≥98% (HPLC)
S4400 Staurosporine from Streptomyces sp. ≥95% (HPLC), film
S3939 Staurosporine aglycone ≥95%
S8567 SU 4312 ≥98% (HPLC)
S8442 SU 5416 ≥98% (HPLC)
S9692 SU 6656 ≥98% (HPLC)
S1693 SU 9516 ≥98% (HPLC), crystalline
T6951 TBBz ≥98% (HPLC), powder
T7040 Tyrphostin 1 ≥98%
T7165 Tyrphostin 23 ≥98%
T7665 Tyrphostin 51 ≥98%
T182 Tyrphostin A9 solid
T6318 Tyrphostin AG 34 ≥98%, solid
T6443 Tyrphostin AG 370 ≥98%
T4443 Tyrphostin AG 527 ≥98%
T4568 Tyrphostin AG 528 ~90%
T7697 I-OMe-Tyrphostin AG 538 solid
T5068 Tyrphostin AG 658 ≥98%, solid
T5193 Tyrphostin AG 698 ≥98%
T5443 Tyrphostin AG 825 ≥92.5%
T5568 Tyrphostin AG 835 ≥92%
T2067 Tyrphostin AG 879 99% (HPLC)
T5693 Tyrphostin AG 957 ≥98%
T5818 Tyrphostin AG 974 ≥98%, solid
T5943 Tyrphostin AG 1007 ≥98%, solid
T6193 Tyrphostin AG 1112 ≥98%, solid
T4057 Tyrphostin AG 1296 ≥98%
T4182 Tyrphostin AG 1478 ≥98%
T3434 Tyrphostin AG 490 solid
T6568 Tyrphostin RG 13022 ≥98%
T6693 Tyrphostin RG 14620 ≥98%
T4192 Tyrphostin SU 1498 ≥98%
U120 U0126 monoethanolate ≥98% (HPLC), powder
SRP4915 Vaspin human recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)
Y0503 Y-27632 dihydrochloride ≥98% (HPLC)
Z4626 ZM 39923 hydrochloride >98% (HPLC)