Sigma-RBI eHandbook

The RBI eHandbook of Receptor Classification and Signal Transduction contains over 100 entries covering such topics as Intracellular Signaling Enzymes and Receptors, signal transduction, Ion Channels, Non-Peptide Receptors, Synthesis and Metabolism, Peptide Receptors and Peptide Metabolism, Protein Kinase, Serine, Threonine, and Tyrosine Kinases, and Transporters.

Each entry contains a peer-reviewed overview, key references and tables providing valuable information on structure, subtypes, selective agonists, selective antagonists, tissue distribution and much more. The on-line version links directly to hundreds of related products.

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The expanded 5th edition presents concise information on the characterization and classification of a wide range of receptors, ion channels, transporters, neurotransmitter synthesis/metabolism pathways and intracellular signaling enzymes. In addition to updating and revising over 80 previous handbook entries, 26 new entries have been added with a strong focus on kinases and ion channels.

Each peer-reviewed entry consists of an easy-to-read and up-to-date overview of the available information in the area, as well as a list of 12 key references to guide both the new investigator and the experienced researcher in their searches and reviews of the current literature. Each entry includes a table that presents the currently accepted classification of a given receptor, ion channel, enzyme or transporter into its component subtypes and subgroups. It also highlights the pharmacological tools with which to investigate their function and regulation.