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Cell Signaling & Neuroscience

Pathway Slides & Charts

The free Pathway Slides are part of Sigma's growing offering in Cell Signaling and Neuroscience. You can download these slides for your personal use or for educational presentations.


Following the link YFG Bugwill load an overview of the pathway and its links to Your Favorite Gene powered by Ingenuity. There you can explore dynamic pathways and locate products in the context of your research.

Cell Signaling & Neuroscience Pathway Slides

Slide Categories:
   Apoptosis and Cell Cycle
   Cytokines, Growth Factors and Hormones
   Cytoskeleton and Extracellular Matrix
   Gene Regulation and Expression
   G Proteins and Cyclic Nucleotides
   Immune Cell Signaling and Blood
   Ion Channels
    Lipids in Cell Signaling
   Multi-Drug Resistance
   Neurobiology
   Neurotransmission
   Nitric Oxide and Cell Stress
   Protein Phosphorylation
    

Slide No.
 Slide Titles
cube-with-text Launch Pathway
back to top APOPTOSIS AND CELL CYCLE  
1 Programmed Cell Death  
2 Activation and Inhibition of Apoptosis  
3 Mitochondria in Apoptosis  
4 ATM/p53 Signaling Pathway launch-cube
5 Caspase Cascade launch-cube
6 Caspase Activation Intrinsic Pathway  
7 Granzyme B  
8 Fas and Related Proteins with Death Domains  
9 Fas Signaling Pathway  
10 G1 and S Phases of the Cell Cycle  
11 G2 and M Phases of the Cell Cycle  
12 Regulatory Cascade of Cyclin Gene Expression  
13 The p53 Signaling Pathway launch-cube
back to top CYTOKINES, GROWTH FACTORS AND HORMONES  
14 Cytokines, Growth Factors and Hormones
15 Structures of Activin and Inhibin Prototypes and Precursors  
16 Structures of Three Chemokine Receptors  
17 Angiopoietins and their receptors, Tie1 and Tie2  
18 EGF Receptor Signal Transduction Pathway
19 Transmembrane Precursors of EGF Family Members  
20 Possible Receptor Combinations and Ligand–binding with EGF and HGF Families  
21 Actions of Flt-3/Flk-2 Ligand on B Cell Lymphopoiesis in Bone Marrow
22
 New Hedgehog and BMI1
23 IGF Regulation of Apoptosis  
24 IL-13 and IL-4 receptor combinations and binding  
25 IL-18 Production and Role in Immune Response  
26 Neurotrophins and Their Receptors  
27 TrkA Receptor  
28 GDNF Family with Receptors  
29 PDGF Receptors and Actions  
30 Signaling Pathway of TGF-b  
31 Bone Morphogenic Protein  
32 TNF Signaling Pathway  
33 TNF-α and TNF-β (LT) Forms and Receptor Binding  
34 Proposed Balance Between TNF Superfamily Members in Relation to Bone Formation or Destruction  
35 Structure of Receptors and Growth Factors Involved in Vasculogenesis, Angiogenesis and Lymphomagenesis  
36 VEGF Receptor and Ligands  
37 Signal Transduction Pathways Involved in Prolactin Regulation  
38 Insulin Pathway
39 Glucocorticoid Receptor Signaling  
back to top CYTOSKELETON AND EXTRACELLULAR MATRIX  
40 Vascular Endothelial Cell Interactions and Signaling  
41 Integrin Signaling in Cell Survival and Death
42 VEGF Receptor Signaling  
43 The MMP/Cytokine Connection  
44 Events Leading to Angiogenesis and Metastasis  
back to top GENE REGULATION AND EXPRESSION  
45 Transcription Factor Regulation (CREB, Elk-1 and c-Fos)  
46 Hormonal Targeting of Nuclear Complexes to Chromatin  
47 The Jak/Stat Signaling Pathway
48 STAT3 Signaling Pathway  
49 PPAR Signaling Pathway  
50 Formation of Nucleosomes  
51 DNA Compaction into Chromosomes  
52 Early Response Events to Moderate Double Strand Break (DSB) Levels  
53 Cell Cycle Checkpoint and Double Strand Breaks (DSB)  
54 Linkage Between DNA Repair and Chromatin Modification  
55 Hypothetical Model on the Functions of the WRN, BLM and MRE11  
56 mRNP Transport through the Nuclear Pore Complex (NPC)  
57 Cargo Import by the Importinα-Importinβ Pathway  
58 Modular Structure of Transcription Factors  
59 Transcription Activation by Nuclear Receptors  
60 Coupled RNA Splicing and Nuclear Export  
61 RNA Polyadenylation  
62 Mammalian mRNA Polyadenylation Machinery  
63 RNA Maturation  
64 RNA-guided Epigenetic Control of Gene Expression  
65 Phosphorylation-driven Regulatory Switch from Transcription Initiation to Elongation  
back to top G PROTEINS AND CYCLIC NUCLEOTIDES  
66 Cyclic Nucleotide Metabolism - cAMP
67 Cyclic Nucleotide Metabolism - cGMP
68 Diversity of G-Protein-Coupled Receptor Signal Transduction Pathways  
back to top IMMUNE CELL SIGNALING AND BLOOD  
69 T Cell Receptor (TCR) Signaling
70 B Cell Receptor Complexes  
back to top ION CHANNELS  
71 Monovalent Ion Channels  
72 Activation and Inactivation of the Sodium Channel  
73 Ligand-Gated Ion Channel: Structure and Activation Status  
74 Aquaporin Channel Structure  
75 Calcium Channel Structure  
76 Calcium Channel Pore Region  
77 Schematic Representation of the Chloride (CIC) Channel  
78 Schematic Representation of the HCN Channel  
79 2TM Potassium Channel Structure  
80 6TM Potassium Channel Structure  
81 Sodium Channel Structure  
82 Sodium Channel Pore Region  
back to top LIPIDS IN CELL SIGNALING  
83 PTEN Pathway  
84 Lipids in Cell Signaling  
85 Inositol Phosphates  
86 Phosphatidic Acid Synthesis  
87 Signaling by Inositol Phospholipids  
back to top MULTI-DRUG RESISTANCE  
88 Mechanisms In Multi-drug Resistance: ABC-transporters and detoxification enzymes I hepatocytes  
89 ABC-ATPases as Regulatory Transporters for NHRs: chemical sensors for endogenous metabolites and xenobiotics  
90 Domain Organization of Bile Salt Transporter (BSEP)  
91 Domain Organization of Multi-drug Related Protein (MRP1)  
back to top NEUROBIOLOGY  
92 b-Amyloid Plaques  
93
 New Notch-γ-Secretase launch-cube
back to top NEUROTRANSMISSION  
94 Second Messenger Systems Involved in Reward and Addiction  
95 Limbic Reward Circuit  
96 Major Noradrenergic, Dopaminergic and Serotonergic Pathways in the CNS  
97 Intracellular Signaling Pathways Activated by Endothelins  
98 NPY Inhibition of Catecholamine Release  
99 Ascending Pain Pathway  
100 Modulation of Pain Transmission  
101 Mechanism of Action of Selective Monoaminergic Reuptake Inhibitors. Figure A  
102 Mechanism of Action of Selective Monoaminergic Reuptake Inhibitors. Figure B  
103 Drug Activation of Dopaminergic Neurons  
104 Schematic Representation of the GABAB Receptor  
back to top NITRIC OXIDE AND CELL STRESS  
105 Oxidative Stress  
106 Neuronal Nitric Oxide Synthase (nNOS)  
107 Endothelial Nitric Oxide Synthase (eNOS)  
108 Inducible Nitric Oxide Synthase (iNOS)  
109 Nitric Oxide Metabolism  
110 Proteasome/Ubiquitination  
111 Formation of Activated 20S Proteasome  
112 Ubiquitin-Proteasome Pathway  
back to top PROTEIN PHOSPHORYLATION  
113 Mitogen-activated Protein Kinase Cascades
114 Akt Signaling
115 Signaling Pathways Activated by VEGF
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