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Life Science > Cell Biology > Learning Center > Pathway Slides & Charts  > Early Response Events
Cell Signaling & Neuroscience

Early Response Events
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Figure-3b

Early Response Events to Moderate Double Strand Break (DSB) Levels

The MRE11-RAD50-NBS1 (MRN) complex is essential for the initial damage processing of DSBs. Processed DSBs leads to the recruitment and subsequent activation of ATM, which then can phosphorylate its substrates, including MRE11 and NBS1. Phosphorylated NBS1 plays a role in checkpoint activation and can also facilitate the phosphorylation of certain ATM effectors.

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