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Fas and Related Proteins with Death Domains The death domain (DD) of Fas (FADD) shows high-sequence homology to the Drosophila melanogaster protein reaper. The death domain is also found in tumor necrosis factor receptor 1 (TNF-R1), TNF-R1-associated death domain (TRADD), Fas-associated death domain (FADD), and Fas receptor-interaction protein (RIP). Fas and FADD associate through their homologous DD while TNF-R1 and TRADD associate through their homologous DD. References: Baker, S.J., and Reddy, E.P., Modulation of life and death by the TNF receptor superfamily. Oncogene., 17, 3261-3270 (1998). Stanger, B.Z., Looking beneath the surface: the cell death pathway of Fas/APO-1 (CD95). Mol. Med., 2, 7-20 (1996). Golstein, P., et al., Homology between reaper and the cell death domains of Fas and TNF-R1. Cell, 81, 185-186 (1995). |
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