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Cell Signaling & Neuroscience

Modulation of Pain
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Figure-3b

Modulation of Pain Transmission

Modulation of pain transmission in the dorsal horn of the spinal cord, illustrating the interaction of small diameter pain afferents and large diameter mechanoreceptors (touch) afferents, as well as the influence of descending neurons on afferent pain pathways; 5HT: serotonin, NE: norepinephrine. (Adapted from Watson, C., Basic Human Neuroanatomy, An Introductory Atlas, 4th Ed., Little, Brown & Company, Boston, 1991).

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