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Cell Signaling & Neuroscience

Second Messenger Systems

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Figure-3b

Second Messenger Systems Involved in Reward and Addiction

With repeated psychostimulant administration, these are changes in dopaminergic and glutamatergic transmission in the nucleus accumbens. The figure depicts the major second messenger systems in the nucleus accumbens activated by dopamine and glutamate that are influenced by acute and/or repeated psychostimulant injections.

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