Wnt/β-catenin

Wnt signaling is critical in a myriad of biological functions, including cell fate determination, cell migration, cell polarity, organogenesis and neural patterning during embryogenesis. Wnt proteins in the stem cell niche control the behavior of various types of stem cells maintaining them in self-renewing state. The extracellular Wnt proteins stimulate several signal transduction cascades, which are classified into canonical or Wnt/β-catenin pathway and non-canonical or β-catenin-independent pathway. There are 19 mammalian genes that code for cysteine rich Wnt proteins, falling into 12 conserved Wnt subfamilies. Wnt proteins are globular, approximately 40 KDa; they undergo post-translational modifications before they are released into the extracellular cytoplasmic milieu. Wnt proteins are known to act in contact dependent manner as well as across distant tissues. Wnt/β-catenin pathway is the result of a prominent close-range signaling along with beta-catenin.

Read about Wnt/β-catenin signaling pathway.
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SRP4754 WNT-1 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
SRP6560 Wnt-2 human recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
SRP3296 WNT-7A human recombinant, expressed in HEK 293 cells, ≥80% (SDS-PAGE), ≥80% (HPLC)