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Insulin-like Growth Factors (IGF)

Insulin-like growth factors (IGF-I and IGF-II) are mitogenic and anabolic peptides structurally homologous to insulin. IGF-I and -II are single polypeptide chains of approximately 7.5 kDa comprised of 70 and 67 amino acid residues, respectively. IGF-I and -II share 70% homology in amino acid sequence, while IGF-I and proinsulin share 48% homology. Both IGFs are highly conserved between species, with 100% identity among human, bovine and porcine IGFs. Unlike insulin, IGF-I and -II are primarily involved in normal growth and development. Circulating IGF is mainly secreted from the liver and acts as an endocrine signal to distant cells. IGF-IR is a tyrosine kinase receptor with signal transduction pathways that include substrates IRS-1, IRS-2, Shc, and Grb10. IGF-IIR has anabolic functions (like IR) but also shows three distinguishing qualities concerned with growth: signals mitosis, maintains transformed cell phenotype and inhibits apoptosis.

Explore our high quality human and mouse and rat recombinant IGF proteins and receptors for your research needs.

Click here for our entire offering of Growth Factors & Cytokines.
Click here for antibodies to Growth Factors & Cytokines.
Click here for our complete offering of Cell Culture products.

Human recombinant IGF proteins and receptors

Product #

Description

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I1146 R3 IGF-1 human recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
SRP3069 IGF-I human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP0350 IGF-1R active human recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)
SRP3062 IGF-Binding Protein 1 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP3063 IGF-Binding Protein 2 human recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP3067 IGF-Binding Protein-3 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP3064 IGF-Binding Protein 4 human recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP3068 IGF-Binding Protein-5 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP3065 IGF-Binding Protein 6 human recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ≥95% (SDS-PAGE), ≥95% (HPLC), cell culture tested
SRP3066 IGF-Binding Protein 7 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
SRP6021 IGF-BP1 human recombinant, expressed in NSO cells, ≥98% (SDS-PAGE), ≥98% (HPLC)
SRP6495 IGF 1R/CD221 human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
SRP3070 IGF-II human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP3265 IGF-II human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
I3769 Insulin-like Growth Factor-I human IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
I5403 Insulin-Like Growth Factor Binding Protein-2 human recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)
I5278 Insulin-Like Growth Factor Binding Protein-3 human recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)
I4402 Insulin-like Growth Factor Binding Protein-4 human >97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
I8529 Insulin-like Growth Factor Binding Protein-5 human >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
I9029 Insulin-like Growth Factor Binding Protein-6 human >97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
I2526 Insulin-like Growth Factor-II human IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
I4657 Insulin-like Growth Factor-I Receptor human ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
H8166 pro Insulin-like Growth Factor-II human recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

Mouse/Rat recombinant IGF proteins and receptors

Product #

Description

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SRP4121 IGF-I from rat recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
I8779 Insulin-like Growth Factor-I from mouse IGF-I, recombinant, expressed in E. coli, lyophilized powder, cell culture tested
I3657 Insulin-Like Growth Factor Binding Protein-2 from mouse ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested
I3782 Insulin-like Growth Factor Binding Protein-5 from mouse ≥90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
I8904 Insulin-like Growth Factor-II from mouse IGF-II, recombinant, expressed in E. coli, lyophilized powder