Vascular Endothelial Growth Factor (VEGF)

Vascular endothelial growth factor (VEGF) is a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. Originally known simply as VEGF, vasculotropin (VAS) or vascular permeability factor (VPF), this factor is now sometimes called VEGF-A. Four additional family members (placental growth factor, PlGF; VEGFB; VEGF-C; and VEGF-D) have been identified to date.
VEGF-A (VEGF) is a potent growth factor for blood vessel endothelial cells, showing pleiotropic responses that facilitate cell migration, proliferation, tube formation, and survival. It is also one of the most potent permeability factors, and a common link of inflammation, permeability and angiogenesis. Due to alternative splicing of a single gene, VEGF-A may exist in four isoforms, designated by their expected final amino acid length (VEGF121, VEGF165, VEGF189 and VEGF206). These isoforms show similar biological activities but bind with different affinities to the heparin and result in different secretion patterns. VEGF-A exerts its actions through two receptors (VEGFR-1 and VEGFR-2).

Read about VEGF signaling pathway .
Click here for our entire offering of Growth Factors & Cytokines.
Click here for antibodies to Growth Factors & Cytokines.
Click here for our complete offering of Cell Culture products.

Explore our high quality human and mouse and rat recombinant VEGF and PlGF proteins and receptors for your research needs.

Human recombinant VEGF proteins and receptors

Product #

Description

Add to Cart

SRP4571 EG-VEGF human recombinant, expressed in mouse cell line, ≥98% (SDS-PAGE), ≥98% (HPLC)
SRP3029 EG-VEGF human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
V7259 Vascular Endothelial Growth Factor human VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture
H9041 Vascular Endothelial Growth Factor 121 human VEGF121, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
H9166 Vascular Endothelial Growth Factor 165 human VEGF165, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
V3388 Vascular Endothelial Growth Factor (aa 207-318) human ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
SRP3182 VEGF human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP4642 VEGF-B human recombinant, expressed in E. coli
SRP3183 VEGF-B human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP6255 VEGF-B human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
SRP4633 VEGF-C human recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
SRP3184 VEGF-C human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), cell culture tested
SRP6256 VEGF-C human recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)
SRP3185 VEGF-D human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), cell culture tested
V5890 VEGF121 recombinant, expressed in HEK 293 cells, suitable for cell culture
V5765 VEGF165 recombinant, expressed in HEK 293 cells, suitable for cell culture
SRP4363 VEGF165 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
SRP6262 VEGFR1/Flt-1 human recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE)
SRP6061 VEGFR2 human recombinant, expressed in insect cells, ≥95% (SDS-PAGE)
SRP6406 VEGFR2/Flk-1/KDR human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
V6758 VEGF Receptor-2 (Flk-1, KDR)/Fc Chimera human >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
V1385 VEGF Receptor-1 (Flt-1)/Fc Chimera human >90% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

Mouse/Rat recombinant VEGF proteins and receptors

Product #

Description

Add to Cart

V4512 Vascular Endothelial Growth Factor from mouse VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture
V3638 Vascular Endothelial Growth Factor 164 from rat >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
SRP4634 VEGF-C from mouse recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
SRP6020 VEGF-C from rat recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
SRP6429 VEGF120 from mouse recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
SRP4964 VEGF121 murine recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
SRP6430 VEGF164 from mouse recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
SRP4364 VEGF165 from mouse recombinant, expressed in E. coli
SRP4365 VEGF165 from rat recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
V6137 VEGF Receptor-1 (Flt-1)/Fc Chimera from mouse ≥90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested

Placenta Growth Factor

Placenta Growth Factor (PlGF), expressed in the placenta, may act as an autocrine on trophoblasts, which express both PlGF and its receptor (VEGFR-1). Since these cells also make VEGF-A, natural heterodimers (PlGF/VEGF-A) have also been detected. Two alternatively spliced isoforms of PlGF have been identified so far.

Product #

Description

Add to Cart

P1588 Placenta Growth Factor human PlGF, recombinant, expressed in E. coli, powder, suitable for cell culture
P5739 Placenta Growth Factor-2 from mouse lyophilized powder, recombinant, expressed in baculovirus infected Sf21 cells, cell culture tested
SRP4743 PLGF from mouse recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
SRP4739 PLGF-1 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
SRP4741 PLGF-2 human recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
SRP3144 PLGF-3 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), cell culture tested
SRP3145 PLGF-I human Animal-component free, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), cell culture tested
SRP6263 PLGF/PIGF2/PGF human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)