Tumor Necrosis Factor (TNF) Superfamily

The tumor necrosis factor (TNF) superfamily comprises structurally related ligand-receptor pairs, including TNF-a, TNF-β (lymphotoxin, LT), TNFR1, TNFR2, LT-ßR, osteoprotegrin (OPG), RANK, RANKL (TRANCE), TRAIL (APO-2L), DR4 (TRAIL-R1), DR5 (TRAIL-R2), DcR1 (decoy receptor 1, TRAIL-R3), and DcR2 (decoy receptor 2, TRAIL-R4). Except p75NGF, all receptors to the TNF superfamily bind TNF-related ligands and act mainly on the immune system. p75NGF is distinctly homologous to TNF receptors, but binds neurotrophins (NGF, BDNF, NT-3 and NT-4) and exerts its actions on the nervous system. TNF superfamily plays important roles in lymphoid development and in T and B cell responses. Several TNF superfamily receptors induce apoptosis, but many TNF members may also induce lymphocyte proliferation and differentiation through costimulation with antigen receptors.

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Human recombinant TNF proteins and receptors

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SRP3002 4-1BBL human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP6397 CD30/TNFRSF8 human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
SRP3036 Fas Ligand human recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC), cell culture tested
SRP6448 Fas Ligand/FasL human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
SRP6471 HVEM/TNFRSF14 human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
SRP3106 LIGHT human recombinant, expressed in Hi-5 Insect cells, ≥96% (SDS-PAGE), ≥96% (HPLC), cell culture tested
SRP3177 TNF-α human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SRP2102 TNFα, low endotoxin, His tagged human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
SRP6389 TNFR1/CD120a/TNFRSF1A human recombinant, expressed in HEK 293 cells, ≥92% (SDS-PAGE)
SRP6047 TNF receptor-associated protein 1 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
SRP6402 TNFRII human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
SRP6453 TNFRSF10B/TRAILR2 human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
SRP6443 TNFRSF4/OX40/CD134 human recombinant, expressed in HEK 293 cells, ≥92% (SDS-PAGE)
SRP6345 TNFSF8 human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
SRP8024 TRAIL, Soluble human recombinant, expressed in E. coli, His tagged, >98% (SDS-PAGE)
T0157 Tumor Necrosis Factor-α human TNF-α, recombinant, expressed in yeast, buffered aqueous solution, suitable for cell culture
T6674 Tumor Necrosis Factor-α human TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture
H8916 Tumor Necrosis Factor-α human TNF-α, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
T7799 Tumor Necrosis Factor-β human TNF-β, recombinant, expressed in E. coli, powder, cell culture tested
11088939001 Tumor Necrosis Factor-α, human (hTNF-α) recombinant (yeast)
11371843001 Tumor Necrosis Factor-α, human (hTNF-α) recombinant (E. coli)
T7189 Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested
T3439 Tumor Necrosis Factor Soluble Receptor I (TNF sRI)/Fc Chimera human >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested
SRP4966 VEGI/TNFSF-15 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Mouse/Rat recombinant TNF proteins and receptors

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SRP3217 LIGHT from mouse recombinant, expressed in E. coli, ≥96% (SDS-PAGE), ≥96% (HPLC), cell culture tested
SRP3237 TRAIL from mouse recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), cell culture tested
SRP6238 TRAIL murine recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
SRP8025 TRAIL, Soluble mouse recombinant, expressed in E. coli, His tagged, >95% (SDS-PAGE)
T7539 Tumor Necrosis Factor-α from mouse TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture
T5944 Tumor Necrosis Factor-α from rat TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture
11271156001 Tumor Necrosis Factor-α, mouse (mTNF-α) recombinant (E. coli)
T3564 Tumor Necrosis Factor Soluble Receptor I (TNF sRI) from mouse >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested