Sigma® Life Science has applied the revolutionary CompoZr® Zinc Finger Nuclease technology to create an unparalleled range of genetically modified mammalian cell lines for use in areas such as basic research, target validation, drug discovery and drug development. With targeted and heritable gene deletions, integrations or modifications our isogenic cell lines give you the tools to take your research to new heights.
CompoZr Cellular Reporters
The study of gene function has been limited by the use of over-expression systems and by tedious staining procedures. To enable scientists to study gene activation, protein function and protein localization in a live cellular system, we have generated engineered human cell lines where several classes of genes are fluorescently tagged at the endogenous locus.
CompoZr Cytoskeletal and Pathway Marker Cell Lines
EGFR Biosensor Cell Line
CompoZr Disease Models
An individual patient's response to therapy may vary depending on their unique genotype. To better understand the genetics of the affliction, we generated genetically defined human cell lines that model the different mutations in the disease. This will enable researchers to study disease gene targets in an isogenic setting and allow better avenues for therapeutic research.
CompoZr Oncology Cell Lines
CompoZr Breast Cancer Cell Lines
The Cell Design Studio group leverages gene editing and gene silencing technologies from CompoZr ZFN and MISSION® shRNA, to create custom-designed genetically engineered mammalian cell lines for use in drug discovery, target validation, disease modelling and other cell-based assays.
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