Functional Genomics & RNAi

Human Ion Channels

Ion channels are gated pores that open and close either intrinsically or in response to regulators such as changes in membrane voltage gradients. They are found in the membranes of virtually all cell types throughout the human body. They regulate passage of ions like calcium, chloride, sodium, and potassium through cell membranes, in and out of cell organelles and play a role in cell-to-cell communication. Their absence or dysfunction can lead to cardiac arrhythmias, diabetes, hypertension, angina pectoris, and cystic fibrosis, to name a few.

Sigma-Aldrich offers the largest and most complete product line in this area, including shRNA target sets and complete gene family sets, antibodies, toxins, inhibitors and activators, cell culture and molecular biology products.

We offer the tools to help you uncover the function of these channels and elucidate their role in disease.



Selected Human Ion Channels
(Please note: These antibodies listed have not been individually validated in knockdown experiments)

Sodium Channels

Gene Symbol RefSeq Description Available Antibody
(Product #)
SCNN1A NM_001038 sodium channel: nonvoltage-gated 1 alpha E4652
SCNN1B NM_011325 sodium channel: nonvoltage-gated 1 beta E4777
SCNN1G NM_001039 sodium channel: nonvoltage-gated 1 gamma E4902
SCN5A NM_000335 sodium channel: voltage-gated type V: alpha (long QT syndrome 3) S0819
S1946
SCN10A NM_009134 sodium channel: voltage-gated type X: alpha polypeptide S2071
SCN11A NM_014139 sodium channel: voltage-gated type XI: alpha S2196
SCN9A NM_002977 sodium channel: voltage-gated type IX: alpha S0645
SCN8A NM_014191 sodium channel: voltage-gated type VIII: alpha S0438
SCN3A XM_355332 sodium channel: voltage-gated type III: alpha polypeptide S6686
SCN4A NM_000334 sodium channel: voltage-gated type IV: alpha S9568

Potassium Channels
2 TM Family

Gene Symbol RefSeq Description Available Antibody
(Product #)
KCNJ1 NM_153764 potassium inwardly-rectifying channel: subfamily J: member 1 P0856
KCNJ2 NM_008425 potassium inwardly-rectifying channel: subfamily J: member 2 P6102
KCNJ12 NM_021012 potassium inwardly-rectifying channel: subfamily J: member 12 P4496
KCNJ4 NM_008427 potassium inwardly-rectifying channel: subfamily J: member 4 P9978
KCNJ3 NM_008426 potassium inwardly-rectifying channel: subfamily J: member 3 P7997
KCNJ6 NM_002240 potassium inwardly-rectifying channel: subfamily J: member 6 P8122
KCNJ9 NM_008429 potassium inwardly-rectifying channel: subfamily J: member 9 P8247
KCNJ5 NM_000890 potassium inwardly-rectifying channel: subfamily J: member 5 P5623
KCNJ10 NM_020269 potassium inwardly-rectifying channel: subfamily J: member 10 P6610
KCNJ15 NM_019664 potassium inwardly-rectifying channel: subfamily J: member 15 P7243
KCNJ8 NM_008428 potassium inwardly-rectifying channel: subfamily J: member 8 P0874
KCNJ11 NM_000525 potassium inwardly-rectifying channel: subfamily J: member 11 P4621

4 TM Family

Gene Symbol RefSeq Description Available Antibody
(Product #)
KCNK3 NM_010608 potassium channel: subfamily K: member 3 P0981
KCNK5 NM_003740 potassium channel: subfamily K: member 5 P1106
KCNK2 NM_014217 potassium channel: subfamily K: member 2 T6448
KCNK6 NM_004823 potassium channel: subfamily K: member 6 P6735

6 TM Family

Gene Symbol RefSeq Description Available Antibody
(Product #)
KCNA1 NM_010595 potassium voltage-gated channel: shaker-related subfamily: member 1 P8607
K1389
KCNA2 NM_004974 potassium voltage-gated channel: shaker-related subfamily: member 2 P8732
KCNA3 NM_002232 potassium voltage-gated channel: shaker-related subfamily: member 3 P9107
P4497
P4247
KCNA4 NM_021275 potassium voltage-gated channel: shaker-related subfamily: member 4 P9232
KCNA5 NM_002234 potassium voltage-gated channel: shaker-related subfamily: member 5 P9357
KCNA6 NM_013568 potassium voltage-gated channel: shaker-related subfamily: member 6 P9482
KCNB1 NM_008420 potassium voltage-gated channel: Shab-related subfamily: member 1 P9607
KCNC1 NM_004976 potassium voltage-gated channel: Shaw-related subfamily: member 1 P9732
KCNC2 XM_483973 potassium voltage-gated channel: Shaw-related subfamily: member 2 P9857
KCNC4 NM_145922 potassium voltage-gated channel: Shaw-related subfamily: member 4 P9982
KCND2 NM_019697 potassium voltage-gated channel: Shal-related subfamily: member 2 P0233
KCND3 NM_004980 potassium voltage-gated channel: Shal-related subfamily: member 3 P0358
KCNQ1 NM_000218 potassium voltage-gated channel: KQT-like subfamily: member 1 P5372
KCNQ3 NM_152923 potassium voltage-gated channel: subfamily Q: member 3 P5121
KCNH2 NM_000238 potassium voltage-gated channel: subfamily H (eag-related): member 2 P4996
KCNH1 NM_002238 potassium voltage-gated channel: subfamily H (eag-related): member 1 P0999
KCR1 XM_047770 modifier of the HERG potassium channel P9497
P8482
P0749
KCNMA1 NM_002247 potassium large conductance calcium-activated channel: subfamily M: alpha member 1 P8357
P4872
KCNMB1 NM_004137 potassium large conductance calcium-activated channel: subfamily M: beta member 1 P1124
KCNMB4 NM_014505 potassium large conductance calcium-activated channel: subfamily M: beta member 4 P1249
KCNN1 NM_002248 potassium intermediate/small conductance calcium-activated channel: subfamily N: member 1 P9372
KCNN3 NM_080466 potassium intermediate/small conductance calcium-activated channel: subfamily N: member 3 P4747
P0608
KCNN4 NM_002250 potassium intermediate/small conductance calcium-activated channel: subfamily N: member 4 P4997
KCNN2 NM_021614 potassium intermediate/small conductance calcium-activated channel: subfamily N: member 2 P0483

Other

Gene Symbol RefSeq Description Available Antibody
(Product #)
HCN1 NM_021072 hyperpolarization activated cyclic nucleotide-gated potassium channel 1 H3038
HCN2 NM_001194 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 H2769
HCN4 NM_005477 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 H0284
KCNE1 NM_000219 potassium voltage-gated channel: Isk-related family: member 1 P3709
KCNE2 NM_172201 potassium voltage-gated channel: Isk-related family: member 2 M3318

Chloride Channels

Gene Symbol RefSeq Description Available Antibody
(Product #)
CLCN1 NM_000083 chloride channel 1: skeletal muscle (Thomsen disease: autosomal dominant) C9347
CLCN2 NM_004366 chloride channel 2 C9477
CLCN3 NM_001829 chloride channel 3 C9602
CLCN5 NM_000084 chloride channel 5 (nephrolithiasis 2: X-linked: Dent disease) C1116

Calcium Channels

Gene Symbol RefSeq Description Available Antibody
(Product #)
CACNA1A NM_000068 calcium channel: voltage-dependent: P/Q type: alpha 1A subunit C1353
CACNA1B NM_000718 calcium channel: voltage-dependent: L type: alpha 1B subunit C1478
CACNA1C NM_000719 calcium channel: voltage-dependent: L type: alpha 1C subunit C4980
C1241
C1603
CACNA1D NM_000719 calcium channel: voltage-dependent: L type: alpha 1D subunit C1728
CACNA1E NM_000721 calcium channel: voltage-dependent: alpha 1E subunit C1853
CACNA1G NM_009783 calcium channel: voltage-dependent: T type: alpha 1G subunit C5488
C2240
CACNA1l NM_021096 calcium channel: voltage-dependent: alpha 1l subunit C4616
CACNA2D1 NM_000722 calcium channel: voltage-dependent: alpha 2/delta subunit 1 C5105
CACNB1 NM_000723 calcium channel: voltage-dependent: beta 1 subunit C5988
CACNB2 NM_000724 calcium channel: voltage-dependent: beta 2 subunit C5738
CACNB3 NM_000725 calcium channel: voltage-dependent: beta 3 subunit C1978
CACNB4 NM_000726 calcium channel: voltage-dependent: beta 4 subunit C5863
CACNG1 NM_000727 calcium channel: voltage-dependent: gamma subunit 1 C6113
CACNG2 NM_006078 calcium channel: voltage-dependent: gamma subunit 2 C8206
CACNG3 NM_006539 calcium channel: voltage-dependent: gamma subunit 3 C6238
CACNG4 NM_014405 calcium channel: voltage-dependent: gamma subunit 4 C6363
CACNG5 NM_014404 calcium channel: voltage-dependent: gamma subunit 5 C6488


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