Human Ion Channels

Ion channels are gated pores that open and close either intrinsically or in response to regulators such as changes in membrane voltage gradients. They are found in the membranes of virtually all cell types throughout the human body. They regulate passage of ions like calcium, chloride, sodium, and potassium through cell membranes, in and out of cell organelles and play a role in cell-to-cell communication. Their absence or dysfunction can lead to cardiac arrhythmias, diabetes, hypertension, angina pectoris, and cystic fibrosis, to name a few.

Sigma-Aldrich offers the largest and most complete product line in this area, including shRNA target sets and complete gene family sets, antibodies, toxins, inhibitors and activators, cell culture and molecular biology products.

We offer the tools to help you uncover the function of these channels and elucidate their role in disease.

Selected Human Ion Channels
(Please note: These antibodies listed have not been individually validated in knockdown experiments)

Sodium Channels

Potassium Channels
2 TM Family

4 TM Family

6 TM Family

Other

Chloride Channels

Calcium Channels

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