Life Science > Functional Genomics & RNAi > MicroRNA/Non-Coding RNA
Non-Coding RNA

Non-Coding RNA Research Tools

Complete Non-Coding RNA Solutions from Screening to Validation

The Non-Coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. Non-coding RNAs have been shown to be involved in many cellular processes, gene regulation and disease states. Non-coding RNA genes include highly abundant and functionally important RNAs such as transfer RNA (tRNA) and ribosomal RNA (rRNA), as well as RNAs such as microRNAs, snoRNAs, siRNAs and piRNAs and the long ncRNAs. Sigma® is proud to offer a variety of tools allowing for the screening with non-coding RNAs such as miRNAs, the identification of targets for non-coding RNAs and the validation of these targets, all part of our growing portfolio of ncRNA research tools.



Products


Identification
  • Collaboration between Kings College of London and Sigma-Aldrich®
  • Human cDNA library cloned downstream of a fusion construct allowing positive and negative selection
  • Enables global identification of biologically relevant RNA targets regulated by microRNAs and other non-coding RNAs, RNA binding proteins and any other factors that affect mRNA stability

Screening
Tool Box
Special Offers
  Validation
  • Collaboration between SwitchGear Genomics and Sigma-Aldrich®
  • Over 10,000 human 3'UTRs in lentiviral vector
  • Optimized LightSwitch companion reagents
  • Enhanced luciferase reporter for more efficient validation and quantification of functional miRNA targets at the 3'UTR region


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