Certain features of will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Functional Genomics & RNAi


Advanced siRNA design and quality synthesis are crucial for a successful RNA interference experiment. Sigma's predesigned siRNA and siRNA libraries were designed using the Rosetta siRNA Design Algorithm to reduce off-target effects and provide guaranteed gene silencing. Coupled with our custom siRNA synthesis services and siRNA transfection reagents, we offer industry-leading technologies that enhance RNAi research.

For in vivo research, Sigma® provides MISSION® In Vivo Quality and iScale Oligos™ siRNA that deliver highly purified siRNA at the quantity necessary for successful in vivo experiments. Our expertise in oligo manufacturing allows us to offer a variety of modifications and scales suitable for any stage in your in vivo research.