Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

siRNA

Pre-arrayed siRNA Libraries

MISSION siRNA

MISSION® siRNA Libraries offer the most compelling siRNA collections for high-throughput screening by targeting genes of high therapeutic value as defined with input from major pharmaceutical companies. The flexible format of MISSION siRNA libraries facilitates research for life scientists who are interested in specific classes of genes as well as those who need to generate information across the entire druggable genome.

Great Introductory Discounts Available on all MISSION siRNA Libraries
Request a quote today at MISSIONRNAi@sial.com

Ordering MISSION siRNA for Single Gene Targets

We've made ordering MISSION siRNA for single gene targets easy through Sigma's state-of-the-art web interface.

To find a MISSION siRNA that knocks down your gene, simply search on your gene of interest by gene name, symbol, RefSeq, or Gene ID number.

Benefits of MISSION siRNA Libraries:

  • siRNA designed using the powerful Rosetta siRNA Design Algorithm, providing for more efficient gene knockdown and greater target specificity
  • 3 individual siRNA provided per gene, allowing for optional siRNA pooling steps
  • siRNA provided at quantities to allow for multiple screenings and hit follow-up
  • Gene targets picked in collaboration with major pharmaceutical company, and based on latest NCBI classifications

MISSION siRNA Library Format:

  • 21mer siRNA duplexes with TT overhangs
  • 3 individual siRNA duplexes per target gene
  • All siRNA duplexes spotted in 96 well microplates with 80 duplexes per plate. First and last columns of each plate are empty.

Ordering Information

MISSION siRNA Human Kinase Panel

MISSION siRNA Human Druggable Genome

MISSION siRNA Rat Druggable Genome

MISSION siRNA Mouse Kinase Library


Selected Citations—MISSION Predesigned siRNA and Pre-arrayed siRNA Libraries

Gilot, D. et al. RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity. PLoS ONE 2011, 6(3): e18261

Meng, W. et al. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell 2008 Nov 28, 135(5), 948-59.

Matsubara, T. et al. BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation. J. Biol. Chem. Oct 2008, 283(43), 29119-25. Epub 2008 Aug 14.

Zhou, H. et al. Genome-Scale RNAi Screen for Host Factors Required for HIV Replication. Cell Host Microbe 2008 Oct 29. [Epub ahead of print].

Marine, S. et al. Activity profile-based siRNA screen to explore the functional genomics of Alzheimer’s disease. BioTechniques Dec 2007, 43, Supplement, Large-Scale Genomic Analysis: S22–S27.

Espeseth, A. S. et al. Genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels. Mol. Cell. Neurosci. Nov 2006, 33(3), 227–35.

Bartz, S. R. et al. Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions. Mol. Cell. Biol. Dec 2006, 26(24), 9377–86.

Majercak, J. et al.LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer’s disease. Proc. Natl. Acad. Sci. U.S.A. Nov 2006, 103(47) 17967–72.



Contact Us

For questions about the library, pricing and quotes or other concerns, please e-mail us at: MISSIONRNAi@sial.com.

MISSION is a trademark of Sigma-Aldrich. Label License.

back to top
RNAi Homepage