Functional Genomics & RNAi Zinc Finger Nuclease (ZFN)

CompoZr^® Zinc Finger Nuclease Technology

Zinc finger nucleases (ZFNs) are a class of engineered DNA-binding proteins that facilitate targeted editing of the genome by creating double-strand breaks in DNA at user-specified locations.

Double-strand breaks are important for site-specific mutagenesis in that they stimulate the cell’s natural DNA-repair processes, namely homologous recombination and Non-Homologous End Joining (NHEJ).

Using well-established and robust protocols, these cellular processes can be harnessed to generate precisely targeted genomic edits resulting in cell lines, including somatic cell lines, with targeted gene deletions (Knockouts), integrations, or modifications.

Learning Center: Visit CompoZrZFN.com What is ZFN Technology? How do ZFNs Work? ZFNs in Animals Tool Box: Your Favorite Gene Search

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