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Functional Genomics & RNAi
Zinc Finger Nuclease (ZFN) | ||
CompoZr™ Zinc Finger Nuclease Technology
Zinc finger nucleases (ZFNs) are a class of engineered DNA-binding proteins that facilitate targeted editing of the genome by creating double-strand breaks in DNA at user-specified locations.
Double-strand breaks are important for site-specific mutagenesis in that they stimulate the cell’s natural DNA-repair processes, namely homologous recombination and Non-Homologous End Joining (NHEJ).
Using well-established and robust protocols, these cellular processes can be harnessed to generate precisely targeted genomic edits resulting in cell lines, including somatic cell lines, with targeted gene deletions (Knockouts), integrations, or modifications.
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Sigma-Aldrich® Receives Award from Michael J. Fox Foundation to Develop Parkinson's Disease Research Models
Sigma-Aldrich and Sangamo BioSciences Announce Major Expansion of ZFP Technology License Agreement
New Sigma® Advanced Genetic Engineering Labs Offers Research Community Unique Rodent Models Developed Using Exclusive Gene-Editing Technology
Visit www.compozrzfn.com to watch the introductory video and enter
the Edit Your World contest.
To Order a CompoZr Zinc Finger Nuclease
Please fill out the CompoZr ZFN Order Form and a Sigma® representative will contact you in regards to your inquiry. For the information on label licenses, visit the ZFN Label License page.
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