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Functional Genomics & RNAi
CompoZr® Zinc Finger Nuclease References
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Publications
Posters
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Publications
Gene Knockout:
Liu, P. et al. 2010. Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases. Biotechnol Bioeng. Advance Online Publication.
Cost, G.J. et al. 2010. BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells. Biotechnol Bioeng. 105(2): 330-40.
Santiago, Y. et al. 2008. Targeted gene knockout in mammalian cells using engineered zinc finger nucleases. Proc Natl Acad Sci USA. 105(15): 5809-14.
Perez, E.E. et al. 2008. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol. 26: 808–816.
Endogenous Gene Correction:
Urnov, F. D. et al. 2005. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature. 435(7042): 646-51.
Targeted Gene Integration:
Moehle, E.A. et al. 2007. Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases. Proc Natl Acad Sci USA. 104(9): 3055-60.
Stem Cell Gene Manipulation:
Hockemeyer, D. et al. 2009. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol. 27(4): 851-7.
Brunet, E. et al. 2009. Chromosomal translocations induced at specified loci in human stem cells. Proc Natl Acad Sci USA. 105(26):10620–5.
Lombardo, A. et al. 2007. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol. 25(11): 1298-306.
Animal Gene Manipulation:
Mashimo, T. et al., 2010. Generation of Knockout Rats with X-linked Severe Combined Immunodeficiency (X-SCID) using Zinc Finger Nucleases. PLoS ONE 5(1): e8870.
Geurts, A.M. et al., 2009. Knockout rats via embryo microinjection of zinc-finger nucleases. Science. 325(5939): 433.
Doyon, Y. et al. 2008. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nat Biotechnol. 26(6): 702.
Zinc Finger Protein Specificity:
Miller, J.C. et al. 2007. An improved zinc-finger nuclease architecture for highly specific genome editing. Nat Biotechnol. 25(7): 778-85.
Targeting of Mitochondrial DNA:
Minczuk, M. et al. 2008. Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA. Nucleic Acids Research. 36(12): 3926-38.
Posters
Expression of miRNA Genes Using Targeted Genomic Integration
Precision Genome Editing in Mammalian Cells Using Engineered Zinc Finger Proteins
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