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Current Issue
Utilizing Pooled Lentiviral shRNA Screens to Identify Essential Cancer Pathways
Volume 8, Number 14
Abstract
Pooled shRNA screening using the highly validated MISSION® shRNA library provides a cost-effective method to investigate gene function and identify therapeutic targets. Here, we present data demonstrating the power and ease of use of the pooled shRNA approach to identify therapeutic targets.
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Recent Issues
- Vol. 8, No. 13, Using PEPscreen™ to Study Protein Phosphorylation and Kinase Activity
- Vol. 8, No. 12, The Role of Liver Transporters in Drug-Drug Interactions
- Vol. 8, No. 11, Detect, Visualize and Quantify Single Post-Translational Modifications
- Vol. 8, No. 10, Neuropsychiatric Disorders and Cell Signaling
- Vol. 8, No. 9, Autophagy in Cancer Promotes Therapeutic Resistance
- Vol. 8, No. 8, The Role of Intestinal Efflux Transporters In Drug Absorption
- Vol. 8, No. 6, Traditional Medicinals and Cancer
- Vol. 8, No. 5, Teaming Seppro® and iTRAQ® for Biomarker Discovery
- Vol. 8, No. 4, Fluorescent G Protein-coupled Receptors (GPCRs)
- Vol. 8, No. 2, New Enzymes for Antibody Characterization
Alternative Energy
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Enzymes and Reagents for Alternative Energy – Volume 5, Number 5
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- Metabolic strategies in Alternative Energy
- Enzyme-based Fuel Cells
- Lignocellulosic Depolymerization
- Enzymes for Biofuel Research
- Reagents for Ethanol and BioDiesel Analysis
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Antibodies
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Antibodies (2.68 Mb PDF) – Volume 3, Number 6
- Prestige Antibodies™
- Antibodies to Actin and GAPDH
- Antibodies to Fusion Tags
- Arrays & Kits
- Secondary Antibodies
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Cancer
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Cancer Metabolism – Volume 7, Number 4
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- Oncogenes and Tumor Suppressors Reprogram Metabolism
- Aerobic Glycolysis and the Warburg Effect
- Glutamine Metabolism
- Fatty Acid Synthesis and Metabolism
- Nucleotide Synthesis in Cancer Cells
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Cancer – Volume 5, Number 6
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- New Cancer Biomarker Discovered
- Tp53 Knockout Rat
- Cancer Research: Epigenetic Mechanisms
- Folic Acid Metabolism: A Role in Cancer's Cause and Cure
- Cell Lines for Cancer Research
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Cancer and Angiogenesis – Volume 4, Number 7
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- VEGF, VEGFR, PDGFR and Non-Receptor Tyrosine Kinase Inhibitors
- Antibodies
- Antioxidants and Cytoprotectants
- Microtubule Inhibitors
- DNA and RNA Transcription Regulation
- DNMT and HDAC Inhibitors
- Gene Expression by qRT-PCR
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Cancer Origins and Carcinogenesis (3.06 Mb PDF) –Volume 3, Number 5
- The Cancer Stem Cell Hypothesis
- Carcinogenesis and Epigenetics
- Imprint™ Chromatin Immunoprecipitation Kit
- Imprint DNA Modification Kit
- MISSION® siRNA Druggable Genome Libraries
- Carcinogen Selector
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Cellular Mechanisms and Cancer (1.01 Mb PDF) – Volume 2, Number 4
- Innovation @ Work
- ABC Transporters and Cancer Drug Resistance
- NF-kB and Innflammation
- DNA Damage and Repair
- New Products
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Carbohydrate Analysis
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Complex Carbohydrate Analysis: Enzymes, Kits, and Reagents (1.06 Mb PDF) – Volume 2, Number 3
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- Agarose
- Alginic Acid
- Cellulose Lichenin and Glucans
- Hemicellulose and Xylan
- Chitin and Chitosan
- Chondroitins
- Dextran
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- Heprarans
- Hyaluronic Acid
- Inulin
- Peptidoglycan
- Pectin
- Pullulan
- Starch and Glycogen
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Cell Culture
Cell Culture Contamination
Volume 7, Number 1
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• Antibiotics
• Mycoplasma Detection/Elimination
• Endotoxin Testing
• Cell Culture Equipment
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Cell-Based Assays
Volume 5, Number 8
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• Assays and Reagents for
Measuring Cytotoxicity,
Proliferation, and Viability
• Apoptosis
• Autophagy
• Reactive Oxygen Species
• Lopac Library
• Cell and Organelle Labeling
• Cell Culture – Cell Lines
• Cell Culture Labware
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Cryopreservation
Volume 5, Number 4
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• New Products
• Cell Freezing Media and Reagents
• ECACC Cell Lines
• Protocol for the Cryopreservation
of Cell Lines
• Cryoware
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Vaccine Adjuvants
Volume 5, Number 3
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• Adjuvant Research
• New Approaches to Vaccine
Adjuvants
• Vaccine Media
• Life Science Labware
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Growth Factors and Cytokines
Volume 4, Number 5
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• Growth Factors
• Cytokines
• Fetal Bovine Serum
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Attachment and Matrix Factors (3.35 Mb PDF)
Volume 3, Number 8
• Attachment and Matrix Factors
• Cell Attachment
• Troubleshooting Guide
• 3-D Cell Culture Technology
• Corning® Plasticware
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Cell Dissociation and Lysis
Enzymes for Cell Dissociation and Lysis (4.49 Mb PDF)
Volume 1, Number 2
• Detachment of Cultured cells
• Lysis and Protoplast preparation
of yeast, bacteria and plant cells
• Permeabiliaztion of Mammalian
Cells
• Mitochondria Isolation
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Centrifugation
Centrifugation
Volume 6, Number 5
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• Centrifugation Basics
• Centrifugation Separations
• Histopaque® Troubleshooting
Guide
• Cell Viability and Proliferation
• Organelle Isolation
• ECACC Cell Lines
• Centrifugation Equipment
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Detection
Superior Fluorescent Products
Volume 6, Number 3
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• Atto Dyes for Superior
Fluorescent Imaging
• Analyzing Properties for Superior
Fluorescent Dyes
• Atto Dyes and Tracy Dyes for
Fluorescent Protein Labeling
• Fluorescent Multiplex Detection
Using Antibody Atto Dye
Conjugates
• Sensitive Detection of poly(his)-
tagged Proteins with Ni-NTA
Atto Complex
• Atto Dye Lectin Conjugates for
Fluorescent Carbohydrate
Labeleing
• Sensor Dyes
• New Products for Detection
Applications
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Protein Characterization & Detection
Volume 5, Number 2
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• Protein Labeling
• Crystallization
• MALDI Mass Spectrometry
• Isoelectric Focusing
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Detergents
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Epigenetics
Epigenetics
Volume 7, Number 3
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• Introduction to DNA Methylation
• DNA Methylation and Bisulfite
Conversion
• Global DNA Methylation
Quantification
• Modulators and Proteins for
Methylation
• Histone Modification and
Chromatin Remodeling
• Antibodies for Epigenetics
Research
• RNAi Tools for Epigenetics
Research
• CompoZr® Zinc Finger Nucleases
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Genomics
Genomics (2.96 Mb PDF)
Volume 3, Number 1
• Genomics Workflow
• RNA Purification
• Plasmid DNA Purification
• Genomic DNA Purification
• Intergrated Extraction and
Amplification
• Whole Transcriptome
Amplification
• Whole Genome Amplification
• Quantitative PCR
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Glycobiology
Glycobiology
Volume 5, Number 1
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• Sialic Acid Synthesis and
Signaling
• Mass Spectrometry of Glycans
• Histological Detection of
Pathogenic Fungi in Human Tissue
• Select-HA™
• New Products for Glycobiology
and Glycochemistry
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Glycobiology-Glycosaminoglycans and Polysaccharides (2.96 Mb PDF)
Volume 3, Number 10
• Glycosaminoglycan Sulfation
and Sign
• Dextrans and Related
Polysaccharides
• GlycoProfile β-Elimination Kit
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Glycobiology (5.46 Mb PDF)
Volume 2, Number 1
• Glycosyltransferase
• Glycoprotein
• Deglycosylation
• Enzymes for Glycobiology
• Glycoprofile™ Labeling Kits
• Glycoprofile™ Azido Sugars
• Glycan Standards
• Galectins And Lectins
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Metabolomics
Metabolic Syndrome and Insulin Resistance
Volume 6, Number 4
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• Insulin Signaling and Energy
Homeostasis
• Lipid Induced Insulin Resistance
• Mitochondrial Dysfunction and
Metabolic Defects
• Mitochondrial Stress and Reactive
Oxygen Species
• Sigma-Aldrich Microarray Tools
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Drug Metabolism
Volume 6, Number 1
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• Drug Transport
• Phase 1 Drug Metabolism
• Drug Conjugate Analysis
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Lipid Metabolism
Volume 5, Number 7
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• Natural Abundance Lipid
Metabolites
• Isotopically Labeled Metabolites
• Characteristic Metabolites for
Inborn Errors of Lipid Metabolism
• Lipid Metabolites as Biomarkers
• Altered Lipid Metabolites in Aging
• Lipid Metabolites in Natural
Product Biosynthesis
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Metabolomics
Volume 4, Number 8
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• Natural Product Biosynthesis
• Disease State Biomarkers
• Inborn Error Metabolism
• Staple Isotopes-Labeled
Metabolic Studies
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Stem Cell models for Drug Discovery & Metabolomics Research (3.0 Mb PDF)
Volume 3, Number 7
• Stemline® Stem Cell Media
• Stem Cell Reagents and
Antibodies
• Drug Discovery
• Metabolite Libraries
• Stable Isotope Labeled
Metabolites
• Metabolite Chromatographic
Analysis
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Cholesterol Homeostasis (2.8 Mb PDF)
Volume 2, Number 7
• HMG-CoA Reductase (HMGR)
Assay Kit
• Cholesterol Biosynthesis
• Blocking Absorption of Dietary
Cholesterol
• Cholesterol Transport
• Bile Acids
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Neuroscience
Neurodegenerative Diseases
Volume 7, Number 2
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• Alzheimer's Disease: Antibodies,
Proteins, Peptides and Assays
• Huntington's Disease: Antibodies,
Proteins, and Peptides
• Parkinson's Disease: Antibodies, Proteins, and Peptides
• Differential protein expression in
rat models using the Panorama
Neurobiology Array
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Nutrition Research
Dietary Bioactives
Volume 7, Number 6
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• Phytochemicals
• Polyphenols
• Phenols
• Terpenes and Terpenoids
• Glycosides
• Alkaloids
• Oils and Resin-derived
• Compounds
• Analytical Standards
• Functional Foods
• Fiber and Prebiotics
• Omega-3 Fatty Acids
• Vitamins
• Stable Isotopes
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Nutrition Research
Volume 6, Number 2
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• Probiotics and Human Health
• Metagenomics and Quantitative
PCR
• Prebiotics
• Vitamins for Nutrition Research
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Nutrition Research
Volume 4, Number 6
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• Vitamins
• Plant Bioactive Extraction and
Isolation
• Core Bioreagents
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Nutrition Research (4.94 Mb PDF)
Volume 3, Number 9
• Dietary Terpenes
• Sweet Taste Perception
• Bioactive Nutrient Explorer
• Retinoic Acid and Gene
Expression
• Metabolite Libraries
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Nutrition Research (841 Kb PDF)
Volume 2, Number 2
• Dietary Antioxidants
• Omega-3 Fatty Acids and Heart
Disease
• The Bioactive Nutrient Explorer
• Metabolite Libraries
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Pharmaceutical Drugs
Pharmaceutical Drugs and Drug Candidates
Volume 7, Number 5
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• Antihypertensive Agents
• Angiotensin-Converting Enzyme
(ACE) Inhibitors
• Angiotensin II Receptor Blockers
(ARBs)
• α1-Adrenoreceptor Blockers
• β-Adrenergic Blockers
• Calcium Channel Blockers (CCBs)
• Diuretics
• Antilipemic Agents
• 3-Hydroxy-3-Methylglutaryl
Coenzyme A (HMG-CoA)
Reductase Inhibitors
• Peroxisome Proliferator-Activated
Receptor (PPAR) Agonists
• Acyl–Coenzyme A:Cholesterol
Acyltransferase (ACAT) Inhibitors
• Anticoagulants
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Plasma and Blood
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Protease
Protease Inhibition and Detection (3.79 Mb PDF)
Volume 4, Number 2
• Broad Spectrum Protease
Inhibitors
• Inhibitor Cocktails and Tablets
• Inhibitor Specificity Index
• Protease Detection
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Proteomics
Structural Proteins (13.9 Mb PDF)
Volume 4, Number 4
• Cytoskeletal Proteins
• Extracellular Matrix Proteins
• Adhesion Proteins
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Ultra-pure Protein Tools (3.13 Mb PDF)
Volume 3, Number 2
• BioUltra Proteins, Enzymes and
Peptides
• Proteomics Grade Proteases
• Universal Proteomics Standards
• BioUltra Reagents
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Stem Cell Biology
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