BioFiles Volume 4, Number 8 — Metabolomics

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Table of Contents

• Introduction
• An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides
• Amino Acid Metabolites in Natural Product Biosynthesis
• Amino Acid Metabolites as Biomarkers for the Differentiation of Diseased and Healthy Cells
• Characteristic Metabolites for Inborn Errors of Amino Acid Metabolism
• Altered Amino Acid Metabolites in Aging
• Non-Labeled Amino Acid Metabolites
• Stable Isotope-Labeled Amino Acid Metabolites
• Metabolite Libraries
• New Metabolites from Sigma-Aldrich
• Drug Discovery
  • Custom Packaged Pharmacologically Active Compounds and Metabolites
  • LOPAC®1280: Library of Pharmacologically Active Compounds
• Metabolite Chromatographic Analysis
  • Ascentis® Express HILIC
  • CHROMASOLV® Solvents

Amino Acid Metabolites in Natural Product Biosynthesis

The biosynthesis of nonribosomal peptide natural products can also utilize amino acids which differ from the proteinogenic amino acids required for the ribosomal machinery. Several hundred other building blocks, in addition to the the 20 standard amino acids found in proteins, can be incorporated into the final products of non-ribosomal peptide synthesis. Beside the pathways dependent on nonribosomal peptide synthetases (NRPS), complex natural products are also formed by NRPS-independent pathways. Non-proteinogenic amino acids like 3-amino-5-hydroxy-benzoic acid for the biosynthesis of ansamycin or 3,5-dihydroxyphenylglycine for vancomycin and teicoplanin biosynthesis offer interesting building blocks for a diversity of natural products.

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