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Current Issue
Biowire Spring 2012 		Live Cell Imaging of Signaling Pathways
  • Engineered Cell Line – Addressing the Complexity
  • Cell Design Studio™ – Key Tools for Researchers
  • An Interview with Dr. David Drubin
  • Study Spotlight
    • Apoptosis Detection Kits: Tools for Apoptosis-Inducing Potency Evaluation
    • Using a Novel 3D Perfusion Bioreactor to Culture ß-Actin-RFP Reporter Osteosarcoma
    • Exploring Colon Cancer with Prestige Antibodies® Powered by Atlas Antibodies
    • Nanofiber Scaffold Technology Validated in a Historic Human Implant
  • Methods
    • Detection of Endogenous Pathway Activity in Novel Reporter Cell Lines
    • Detection and Prevention of Cell Line Cross-Contamination

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Previous Biowire Issues



Fall 2011
Biowire Fall 2011		 Screening — microRNA Target Identification
  • microRNA Streamlining the Workflow
  • MISSION® Target ID Library For Human miRNA Target ID and Discovery
  • An Interview with Dr. Joop Gäken
  • Study Spotlights
    • EGF Signaling: Tracing Cancer’s Path
    • Custom PEPscreen™ Peptide Libraries
    • Prestige Antibodies® as Tools in Plasma Profiling
    • High-Throughput Screening of Peptide Substrates for Tyrosine Kinases
  • Methods
    • Pico Profiling: The Road to Single-Cell Transcriptomics
  • Sigma Life Science Global Education Program
  • Social Media in the Life Sciences

Navigate this issue or Download this issue (4.68 Mb PDF)


Spring 2011
Biowire Spring 2011 Cover		 Cell Lines — Models of Disease
  • Modified Cells for Enhanced R&D
  • Cracking the Cancer Code
  • An Interview with Dr. Hakim Djaballah
  • Study Spotlights
    • ADME/Tox Cell Lines: Exploring the Role of Membrane Transporters
    • Effective Immunochemical Analysis with Cell Microarrays
    • Receptors and Inhibitors: Scratching the Surface of Bioactive Small Molecules for EGFR Research
  • Methods
    • Cell Tracking with Lipophilic Membrane Dyes: Applications in Cancer Research
    • EGFR: Exceptional Accuracy for Real-Time, Live-Cell Applications
    • Cell Culture Collections: Exploring the Iceberg
  • Sigma Life Science Global Education Program
  • Social Media in the Life Sciences

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Winter 2011
Biowire Winter 2011 Cover		 Knockout Rats — More Effective Pre-Clinical Models
  • ZFNs In Vivo – Edward Weinstein, Ph. D.
  • Knockout Rats – An Improved Platform
  • An Interview with Dr. Reid Hayward
  • Study Spotlights
    • Featured Pathway: Apoptosis Signaling
    • The Unique Features of Prestige Antibodies®
    • The New Human Protein Atlas
  • Methods
    • MicroRNA Target Validation MISSION® 3’UTR Lenti GoClone™ and Human microRNA Mimics
    • Microarray Protocols
    • Tech Tips: MISSION esiRNA
  • Sigma® Life Science Global Education Program
  • Social Media in the Life Sciences

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Fall 2010
Biowire Fall 2010 Cover		 A Look into the Future of Gene Editing: Zinc Finger Nucleases
  • Genome by Design – Dave Smoller
  • ZFN Technology
  • An Interview with Dana Carroll
  • Tech Tip: ZFN Donor Design
  • Study Spotlights
    • Development of Two Multiplex Immunoassays and Preliminary Application in Determining Protein Depletion
    • Mapping the Human Proteome with Prestige Antibodies®
    • Phosphatase Inhibitor Cocktail
    • TransPlex® Whole Transcriptome RNA Amplification
  • YFG – Discover the Power of Your Favorite Gene Pathways
  • Sigma® Global Education Program
  • Social Space

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