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Enzyme Explorer

Apoptosis Products

The Enzyme Explorer Apoptosis table is organized by your enzyme of interest. Under each enzyme category are listed the corresponding enzymes, substrates, inhibitors and antibodies offered by Sigma. This is only a partial list of reagents Sigma offers for apoptosis research. For additional proteins, antibodies and reagents be sure to visit our Apoptosis pages in our Cell Signaling section.


  Caspases (general)
Caspase 1
Caspase 2
Caspase 3
Caspase 4
Caspase 5
Caspase 6

 Caspase 7
Caspase 8
Caspase 9
Caspase 10
Cathepsin B
Cathepsin C
Cathepsin D

 Cathepsin E
Cathepsin G
Cathepsin L
Granzyme A
Granzyme B
PARP
Calpain
  More Antibodies, Proteins & Reagents for Apoptosis Research
Caspases (general)  
Product Name
Detection
 Product # 
Enzyme Combinations  
Caspase Combo I, Type 1, 4, and 5   C8107
Caspase Combo II, Type 2, 3, and 7   C8232
Caspase Combo III, Type 6, 8, 9 and 10 human   C8357
General Caspase Inhibitors  
Biotin-Val-Ala-Asp(OMe)-fluoromethyl ketone   B2057
Boc-Asp(OMe)-fluoromethyl ketone   B2682
Z-Ala-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone   C8484
Z-Val-Lys(Biotin)-Asp(OMe)-fluoromethyl ketone   C8609
General Caspase Substrates  
N-Acetyl-Val-Ala-Asp p-nitroanilide colorimetric A0848
N-Acetyl-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin fluorimetric A0723
L-Asp-Asp-Rhodamine trifluoroacetate salt fluorimetric D5189
Caspase 1   back to top
Product Name
Detection
 Product # 
Enzyme  
Caspase 1 human   C5482
Inhibitors  
N-Acetyl-Trp-Glu-His-Asp-al   A1466
Interleukin-1b (IL-1b) Converting Enzyme (ICE) Inhibitor II   A4211
N-Acetyl-Tyr-Val-Lys(biotinyl)-Asp 2,6-dimethylbenzoyloxymethyl ketone   A4339
Z-Leu-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone   C9484
Substrates  
N-Acetyl-Tyr-Val-Ala-Asp p-nitroanilide colorimetric A3831
N-Acetyl-Trp-Glu-His-Asp-p-nitroanilide colorimetric A6845
N-Acetyl-Trp-Glu-His-Asp-7-amido-4-methylcoumarin fluorimetric A0216
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin fluorimetric A2452
N-Acetyl-Trp-Glu-His-Asp-7-amide-4-trifluoromethylcoumarin fluorimetric A6720
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin fluorimetric A9965
7-Methoxycoumarin-4-acetyl-Tyr-Val-Ala-Asp-Ala-Pro-(2,4-dinitrophenyl)Lys fluorimetric M5295
Antibodies  
Anti-Caspase 1 (ICE) from rabbit   C4851
Caspase 2   back to top
Product Name
Detection
 Product # 
Enzyme  
Caspase 2 human   C2854
Inhibitors  
N-Acetyl-Val-Asp-Val-Ala-Asp-CHO   A2222
Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone   C1605
Substrates  
N-Acetyl-Val-Asp-Val-Ala-Asp-p-nitroanilide colorimetric A5470
N-Acetyl-Val-Asp-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin fluorimetric A5345
Antibodies  
Anti-Caspase 2 from rabbit   C7349
Caspase 3   back to top
Product Name
Detection
 Product # 
Enzymes  
Caspase 3 human   C1224
Procaspase-3 human   P1488
Inhibitors  
N-Acetyl-Asp-Glu-Val-Asp-al   A0835
N-Acetyl-Ile-Glu-Thr-Asp-al   A1216
N-Acetyl-Glu-Ser-Met-Asp-al   A1341
Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone   B1807
Z-Asp(OMe)-Gln-Met-Asp(OMe) fluoromethyl ketone   C0480
N-Acetyl-Leu-Glu-Val-Asp-CHO trifluoroacetate salt   C0859
Z-VAD-FMK   V-116
Substrates  
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide colorimetric A2559
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin fluorimetric A0466
Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin fluorimetric A1086
N-Acetyl-Asp-Gln-Met-Asp-7-amido-4-trifluoromethylcoumarin fluorimetric A5595
Chromofluor 96 fluorimetric CF96-101
DFF45/ICAD human natural D3815
Antibodies  
Anti-Caspase 3 from rabbit   C9598
Caspase 4   back to top
Product Name
Detection
 Product # 
Enzyme  
Caspase 4 human   C6357
Substrates  
N-Acetyl-Tyr-Val-Ala-Asp p-nitroanilide colorimetric A3831
N-Acetyl-Leu-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin fluorimetric A2099
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin fluorimetric A2452
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin fluorimetric A9965
Antibodies  
Anti-Caspase 4 from rabbit   C4481
Monoclonal Anti-Caspase 4 from mouse   C3392
Caspase 5   back to top
Product Name
Detection
 Product # 
Enzyme  
Caspase 5 human   C6482
Inhibitor  
N-Acetyl-Trp-Glu-His-Asp-al   A1466
Substrates  
N-Acetyl-Trp-Glu-His-Asp-p-nitroanilide colorimetric A6845
N-Acetyl-Trp-Glu-His-Asp-7-amide-4-trifluoromethylcoumarin fluorimetric A6720
Antibodies  
Monoclonal Anti-Caspase 5 from mouse   C6979
Caspase 6   back to top
Product Name
Detection
 Product # 
Enzyme  
Caspase 6 human   C4977
Inhibitors  
N-Acetyl-Val-Glu-Ile-Asp-al   A6339
Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone   B1807
Z-Asp(OMe)-Gln-Met-Asp(OMe) fluoromethyl ketone   C0480
Z-Val-Glu(O-Me)-Ile-Asp(O-Me) fluoromethyl ketone   C1730
Substrates  
N-Acetyl-Val-Glu-Ile-Asp-p-nitroanilide colorimetric A5220
N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-methylcoumarin fluorimetric A0341
N-Acetyl-Val-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salt fluorimetric A2097
N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin fluorimetric A5095
Caspase 6 Assay Kit, Fluorimetric fluorimetric CASP-6-F
Antibodies  
Anti-Caspase 6 from rabbit   C7599
Caspase 7   back to top
Product Name
Detection
 Product # 
Enzyme  
Caspase 7 human   C2979
Inhibitors  
Arachidic anhydride   A2581
Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone   B1807
Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone   C0605
Substrates  
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide colorimetric A2559
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin fluorimetric A0466
Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin fluorimetric A1086
Antibodies  
Monoclonal Anti-Caspase 7 from rat   C1104
Anti-Caspase 7 from rabbit   C7724
Caspase 8   back to top
Product Name
Detection
 Product # 
Enzyme  
Caspase 8 human   C1099
Inhibitors  
N-Acetyl-Ile-Glu-Thr-Asp-al   A1216
Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone   B1807
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone   C1230
Z-Leu-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone   C8734
Substrates  
N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide colorimetric A9968
Caspase 8 Assay Kit, Colorimetric colorimetric CASP-8-C
N-Acetyl-Ala-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin fluorimetric A0973
N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin fluorimetric A4188
N-Acetyl-Leu-Glu-Thr-Asp-7-Amido-4-trifluoromethylcoumarin fluorimetric A6095
Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin fluorimetric C5599
Caspase 8 Assay Kit, Fluorimetric fluorimetric CASP-8-F
Antibodies  
Monoclonal Anti-Caspase 8 from mouse   C4106
Anti-Caspase 8 (GD-13) from rabbit   C2976
Anti-Caspase 8 (SK-16) from rabbit   C3101
Anti-pro-Caspase 8 from rabbit   C7849
Caspase 9   back to top
Product Name
Detection
 Product # 
Enzyme  
Caspase 9 human   C8726
Inhibitor  
Z-Leu-Glu(O-ME)-His-Asp(O-Me) fluoromethyl ketone   C1355
Substrates  
N-Acetyl-Leu-Glu-His-Asp-p-nitroaniline colorimetric A5970
N-Acetyl-Val-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salt fluorimetric A2097
N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin fluorimetric A5845
Antibodies  
Monoclonal Anti-Caspase 9 from mouse   C4356
Anti-Caspase 9 from rabbit   C7729
Anti-Caspase 9 from rabbit   C9235
Caspase 10   back to top
Product Name
Detection
 Product # 
Enzyme  
Caspase 10 human   C6607
Inhibitors  
Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone   B1807
Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-fluoromethyl ketone   C8859
Antibodies  
Monoclonal Anti-Caspase 10 from rat   C1229
Anti-Caspase 10 from rabbit   C8351
Monoclonal Anti-Caspase 11 from rat   C1354
Monoclonal Anti-Caspase 12 from rat   C7611
Anti-Caspase 13 (ERICE) from rabbit   C8854
Cathepsin B   back to top
Product Name
Detection
 Product # 
Enzyme  
Cathepsin B from bovine spleen   C6286
Cathepsin B from human liver   C8571
Inhibitors  
Calpain Inhibitor II   A6060
Calpain Inhibitor I   A6185
Antipain hydrochloride   A6191
Biotin-Phe-Ala-fluoromethyl ketone   B1932
Cystatin from chicken egg white   C0408
CA-074   C5732
CA-074 methyl ester   C5857
Chymostatin   C7268
Cystatin from chicken egg white   C8917
Z-Leu-Leu-Leu-fluoromethyl ketone   C8984
Z-Phe-Phe-fluoromethyl ketone   C9109
E-64   E3132
Leupeptin trifluoroacetate salt   L2023
N-Methoxysuccinyl-Phe-HOMO-Phe-fluoromethyl ketone   M5314
a2-Macroglobulin from human plasma   M6159
Procathepsin B Fragment 26-50, rat   P0350
Procathepsin B Fragment 36-50, rat   P0475
Substrates  
Na-Benzoyl-L-arginine 4-methoxy-b-naphthylamide hydrochloride fluorimetric B0885
Z-Val-Lys-Lys-Arg-4-methoxy-b-naphthylamide trihydrochloride fluorimetric C2772
Z-Phe-Arg 4-methoxy-b-naphthylamide hydrochloride fluorimetric C3282
Z-Arg-Arg-7-amido-4-Z-RR-AMC-methylcoumarin hydrochloride fluorimetric C5429
Z-Arg-Arg 4-methoxy-b-naphthylamide acetate salt fluorimetric C5520
Z-Ala-Arg-Arg 4-methoxy-b-naphthylamide acetate salt fluorimetric C8536
N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin fluorimetric S6510
Hippuryl-Arg Non-chromogenic H2508
Cathepsin C   back to top
Product Name
Detection
 Product # 
Enzyme  
Cathepsin C from bovine spleen   C8511
Substrates  
Gly-Phe p-nitroanilide colorimetric G0142
Gly-Phe b-naphthylamide fluorimetric G4255
Gly-Phe b-naphthylamide fluorimetric G9512
Ser-Tyr b-naphthylamide fluorimetric S5628
Cathepsin D   back to top
Product Name
Detection
 Product # 
Enzymes  
Cathepsin D from bovine spleen   C3138
Cathepsin D from human liver   C8696
Inhibitors  
Antipain hydrochloride   A6191
Chymostatin   C7268
Pepstatin A   P5318
Substrates  
Boc-Phe-Ala-Ala-p-Nitro-Phe-Phe-Val-Leu 4-hydroxymethylpyridine ester colorimetric B1644
N-Acetyl-Arg-Gly-Phe-Phe-Pro-7-amido-4-methylcoumarin fluorimetric C6358
N-Acetyl-Arg-Gly-Phe-Phe-Pro-7-amido-4-trifluoromethylcoumarin fluorimetric C6983
N-Acetyl-Arg-Gly-Phe-Phe-Pro 4-methoxy-2-naphthylamide fluorimetric C7108
7-Methoxycoumarin-4-Acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(DNP)-D-Arg-amide fluorimetric M0938
Antibodies  
Monoclonal Anti-Cathepsin D from mouse   C0715
Cathepsin E   back to top
Product Name
Detection
 Product # 
Substrate  
7-Methoxycoumarin-4-Acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(DNP)-D-Arg-amide fluorimetric M0938
Cathepsin G   back to top
Product Name
Detection
 Product # 
Enzyme  
Cathepsin G from human leukocytes   C4428
Inhibitors  
a1-Antichymotrypsin from human plasma   A9285
Chymostatin   C7268
Z-Gly-Leu-Phe-chloromethyl ketone   C9984
Diisopropyl fluorophosphate   D0879
3,4-Dichloroisocoumarin   D7910
N-Acetyl-eglin C   E7888
Substrates  
N-Methoxysuccinyl-Ala-Ala-Pro-Met p-nitroanilide colorimetric M7771
N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide colorimetric S7388
N-Succinyl-Gly-Gly-Phe-7-amido-4-trifluoromethylcoumarin fluorimetric S4689
N-Succinyl-Gly-Gly-Phe-4-methoxy-2-naphthylamide fluorimetric S4814
N-Succinyl-Ala-Ala-Pro-Phe thiobenzyl ester fluorimetric S6518
N-Succinyl-Phe-Leu-Phe thiobenzyl ester fluorimetric S6643
Cathepsin L   back to top
Product Name
Detection
 Product # 
Enzyme  
Cathepsin L from human liver   C6854
Inhibitors  
Calpain Inhibitor I   A6185
Z-Leu-Leu-Leu-fluoromethyl ketone   C8984
Z-Phe-Phe-fluoromethyl ketone   C9109
Z-Leu-Leu-Tyr-fluoromethyl ketone   C9234
Z-Leu-Leu-Tyr-CHN2   C9859
N-Methoxysuccinyl-Phe-HOMO-Phe-fluoromethyl ketone   M5314
Substrates  
Z-Phe-Arg 4-methoxy-b-naphthylamide hydrochloride fluorimetric C3282
N-Succinyl-Ala-Ala-Pro-Phe p-nitroanilide colorimetric S7388
Antibodies  
Monoclonal Anti-Cathepsin D from mouse   C0715
Granzyme A   back to top
Product Name
Detection
 Product # 
Enzyme  
Granzyme A from mouse   G6041
Substrates  
Z-Gly-Pro-Arg 7-amido-4-methylcoumarin hydrobromide fluorimetric C0855
Z-Gly-Pro-Arg 7-amido-4-trifluoromethylcoumarin fluorimetric C0980
Z-Gly-Pro-Arg 4-methoxy-2-naphthylamide fluorimetric C1105
Granzyme B   back to top
Product Name
Detection
 Product # 
Enzyme  
Granzyme B from mouse   G9278
Inhibitors  
Antipain hydrochloride   A6191
Z-Ala-Ala-Asp(OMe)-chloromethyl ketone   C0235
3,4-Dichloroisocoumarin   D7910
Substrates  
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroaniline colorimetric A6470
N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide colorimetric A9968
N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide colorimetric A9968
N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin fluorimetric A4188
N-Acetyl-Ile-Glu-Pro-Asp-7-amido-4-methylcoumarin fluorimetric A6220
N-Acetyl-Ile-Glu-Pro-Asp-AFC fluorimetric A6345
Boc-Ala-Ala-Asp thiobenzyl ester fluorimetric B5305
Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin fluorimetric C5599
Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin fluorimetric C5599
PARP   back to top
Product Name
Detection
 Product # 
Enzymes  
PARP-1 bovine   P1613
PARP-1 human   P1863
PARP-1 bovine   P1738
PARP-2 from mouse   P1988
Inhibitors  
3-Aminobenzamide   A0788
4-Amino-1,8-naphthalimide   A0966
DPQ   D5314
1,5-Isoquinolinediol   I-138
PJ-34   P4365
6(5H)-Phenanthridinone   P8852
Antibodies  
Monoclonal Anti-PARP mouse   P-248
Anti-PARP from rabbit   P7605
Anti-PARP from rabbit   P1991
Calpain   back to top
Product Name
Detection
 Product # 
Enzymes  
Calpain 1 Human   C6108
Calpain II from rabbit skeletal muscle   P4533
General Inhibitors  
Antipain hydrochloride   A6191
Acetyl-Calpastatin (184-210) Human   C4285
4-Chloromercuribenzoic acid   C5913
Z-Leu-Leu-Tyr-fluoromethyl ketone   C9234
Z-Leu-Leu-Tyr-CHN2   C9859
E-64c   E0514
N-Ethylmaleimide   E3876
E-64d   E8640
Leupeptin trifluoroacetate salt   L2023
N-Methoxysuccinyl-Val-HOMO-Phe-fluoromethyl ketone   M5439
a2-Macroglobulin from human plasma   M6159
Calpain I Inhibitors  
Calpain Inhibitor II   A6060
Calpain Inhibitor I   A6185
Calpain Inhibitor Peptide   C9181
Calpain II Inhibitors  
Calpain Inhibitor II   A6060
Calpain Inhibitor I   A6185
Antipain hydrochloride   A6191
Acetyl-Calpastatin (184-210) Human   C4285
4-Chloromercuribenzoic acid   C5913
Calpain Inhibitor Peptide   C9181
E-64c   E0514
N-Ethylmaleimide   E3876
Leupeptin trifluoroacetate salt   L2023
a2-Macroglobulin from human plasma   M6159
Calpain Substrates  
N-Succinyl-Leu-Tyr-7-amido-4-methylcoumarin fluorimetric S1153
N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin fluorimetric S6510
Antibodies  
Monoclonal Anti-Calpain (28 kDa Subunit) from mouse   C-269
Anti-Calpain-94 (Domain I), Large Subunit from rabbit   C6611
Anti-Calpain-94 (Domain II, Insert 1), Large Subunit from rabbit   C6361
Anti-Calpain-94 (Domain III, Insert 2), Large Subunit from rabbit   C6236
Anti-Calpain-94 (Domain III), Large Subunit from rabbit   C6486
Anti-Calpain LP-82/LP-85 (Lens-Specific Calpain) (Domain-III) Large Subunit from rabbit   C0603
Anti-Calpain LP-85 (Lens-Specific Calpain) (Domain-IV) Large Subunit from rabbit   C0478
Anti-m-Calpain (Domain I), N-Terminal from rabbit   C5861
Anti-m-Calpain (Domain III) from rabbit   C6111
Monoclonal Anti-m-Calpain (Domain III/IV) from mouse   C-268
Anti-m-Calpain (Domain-III, Large Subunit) from rabbit   C0728
Anti-m-Calpain (Domain IV), C-Terminal from rabbit   C5986
Monoclonal Anti-m/µ Calpain, Small Subunit from mouse   C0230
Anti-µ-Calpain (Domain I) from rabbit   C5486
Anti-µ-Calpain (Domain I), N-Terminal from rabbit   C5361
Monoclonal Anti-µ-Calpain (Domain II) from mouse   C-267
Monoclonal Anti-µ-Calpain (Domain III) from mouse   C-266
Anti-µ-Calpain (Domain IV) from rabbit   C5611
Anti-µ-Calpain (Domain IV), C-Terminal from rabbit   C5736
Monoclonal Anti-µ-Calpain, Large Subunit from mouse   C0355

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