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Enzyme Explorer

Proteasome

Determine the fate of your protein.

Explore the pathways of intracellular protein degradation with Sigma's comprehensive line of proteasome, calpain and lysosomal proteases.

Overview of Ubiquitin and the Proteasome Pathway

Product Guide:
Proteasome Pathway
Ubiquitination
Enzymes/Proteins
Prod No.: Product Name:
I 1154 Isopeptidase T *New
U 1633 Ubiquitin Activating Enzyme, Yeast *New
U 1758 Ubiquitin Activating Enzyme, Rabbit *New
U 2133 Ubiquitin C-Terminal Hydrolase, L3 *New
U 8382 Ubiquitin conjugating enzyme fractions (mammalian) *New
U 2633 Ubiquitin Carrier Protein H2 / E2-14K *New
U 2508 Ubiquitin Carrier Protein H2 *New
U 2383 Ubiquitin Carrier Protein H3 *New
U 8632 Ubiquitin-Carrier Protein H5a, GST-tagged human *New
U 8757 Ubiquitin-Carrier Protein H5b human *New
U 8882 Ubiquitin-Carrier Protein H5c human *New
U 9007 Ubiquitin-Carrier Protein H6 human *New
U 9132 Ubiquitin-Carrier Protein H7 human *New
U 9257 Ubiquitin-Carrier Protein H9 human *New
U 9382 Ubiquitin-Carrier Protein H10 human *New
U 5382 Ubiquitin, human, recombinant, N-terminal FLAG-tagged
U 5507 Ubiquitin, human, recombinant, N-terminal his-tagged
U 5632 Ubiquitin-Agarose
U 6253 Ubiquitin from bovine erythrocytes
U 8257 Ubiquitin Fraction FI from HeLa cells *New
U 8507 Ubiquitin K48R *New
Inhibitors
U 1507 Ubiquitin Aldehyde
U 1632 Ubiquitin, Methylated
Substrates
N 2030 NEDD8 precursor (Pro NEDD8) *New
N 8529 NEDD8 *New
S 0314 SUMO-1/Sentrin-1 human *New
S 0439 SUMO-1/Sentrin-1 human *New
U 5379 Anti-Ubiquitin from rabbit
U 2258 Ubiquitin-AMC *New
Proteasomes
Proteasome Fractions
Prod No.: Product Name:
F 3926 Fraction II [FII] (HELA) *New
F 4051 Fraction II [FII] (Rabbit reticulocyte) *New
P 3863 26S Proteasome Fraction from rabbit *New
P 3988 20S proteasome (mammalian) *New
P 4113 S-100 proteasome fraction from HeLa cells *New
Inhibitors
C 0358 CBZ-Leu-Leu-Phe-Al *New
C 2211 N-CBZ-Leu-Leu-Leucinal
C 6706 N-CBZ-Leu-Leu-Norvalinal
C 9857 CBZ-Leu-Leu-Leu-B(OH)2 *New
E 3652 Epoxomicin *New
E 3876 N-Ethylmaleimide
L 7035 clasto-Lactacystin b-lactone
L 6785 Lactacystin
G 9893 Gliotoxin
Substrates
C 0483 Z-Leu-Leu-Glu-7-amido-4-methylcoumarin *New
C 0608 Z-Leu-Leu-Leu-7-amido-4-methylcoumarin *New
C 0788 CBZ-Leu-Leu-Glu-ß-naphthylamide *New
Activator
P 5988 PA28 activator (mammalian) *New
Calpain
Enzymes
Prod No.: Product Name:
C 6108 Calpain I *New
P 4533 Calpain II
Inhibitors
A 6060 N-acetyl-Leu-Leu-Methioninal
A 6185 Calpain Inhibitor I
A 6191 Antipain Hydrochloride
C 4285 Acetyl-Calpastatin (184-210) Human
C 5913 4-Chloromercuribenzoic acid
C 8984 Z-Leu-Leu-Leu-fluoromethyl keytone *New
C 9181 Calpain Inhibitor Peptide
C 9234 Z-Leu-Leu-Tyr-fluoromethyl ketone *New
C 9859 Z-Leu-Leu-Tyr-CHN2 *New
E 0514 E-64c
E 8640 E-64d
L 2023 Leupeptin Trifluoroacetate salt
M 5439 N-Methoxysuccinyl-Val-HOMO-Phe-fluoromethyl ketone *New
M 6159 a2-Macroglobulin
M 6690 MDL 28170 (Calpain III inhibitor) *New
Substrates
S 1153 N-Succinyl-Leu-Tyr 7-amido-4-methylcoumarin
S 6510 Succinyl-Leu-Leu-Val-Tyr 7-amido-4-methylcoumarin
Antibodies
C 0230 Monoclonal Anti-m/5 Calpain, Small Subunit from mouse *New
C 0355 Monoclonal Anti-mu Calpain, Large Subunit, Clone 15C10, Mouse *New
C-269 Anti-Calpain (28 kDa subunit), monoclonal
C 5361 Anti-Mu-Calpain (Domain I) N-terminal
C 5486 Anti-Mu-Calpain (Domain I)
C 5861 Anti-Mu-Calpain (Domain I) N-terminal
C-266 Anti-mu-Calpain (Domain II), monoclonal
C-267 Anti-mu-Calpain (Domain II), monoclonal
C 0728 Anti-mu-Calpain Domain-III, large subunit
C-268 Anti-mu-Calpain (Domain III/IV), monoclonal
C 6111 Anti-M-Calpain (Domain III)
C 0478 Anti-LP-85 (lens-specific Calpain); Domain-IV, large subunit
C 0603 Anti-LP-82 (lens-specific Calpain)and LP-85; Domain-III, large subunit
C 6611 Anti-Calpain-94 (Domain I)
C 6486 Anti-Calpain-94 (Domain III)
C 6361 Anti-Calpain-94 (Domain II-Insert 1)
C 6236 Anti-Calpain-94 (Domain III-Insert 2)
C 5611 Anti-Mu-Calpain (Domain IV)
C 5736 Anti-Mu-Calpain (Domain IV) C-terminal
C 5986 Anti-Mu-Calpain (Domain IV) C-terminal
C-270 Anti-Calpastatin, monoclonal
Lysosomal Proteases
Cathepsin B
Enzymes
Prod No.: Product Name:
C 6286 Cathepsin B from bovine spleen 
C 8571 Cathepsin B from human liver 
C 0150 Cathepsin B from human placenta 
Inhibitors
A 6060 N-Acetyl-Leu-Leu-Met-al
A 6185 N-Acetyl-Leu-Leu-Norleu-al
A 6191 Antipain Hydrochloride
B 1932 Biotin-Phe-Ala-fluoromethyl ketone *New
C 0408 Cystatin
C 5732 CA-074 *New
C 5857 CA-074 Methyl Ester *New
C 7268 Chymostatin
C 8917 Cystatin
C 9109 Z-Phe-Phe-fluoromethyl keytone *New
E 3132 E-64 
L 2023 Leupeptin Trifluoroacetate Salt
M 5314 N-Methoxysuccinyl-Phe-HOMO-Phe-fluoromethyl ketone *New
M 6159 a2-Macroglobulin
P 0350 Procathepsin B Fragment 26-50, rat
P 0475 Procathepsin B Fragment 36-50, rat
Substrates
B 0885 Na-Benzoyl-L-arginine 4-methoxy-ß-naphthylamide HCl
C 2772 Z-Val-Lys-Lys-Arg-4-methoxy-b-naphthylamide trihydrochloride
C 3282 Z-Phe-Arg 4-methoxy-b-naphthylamide hydrochloride
C 5429 Z-Arg-Arg-7-amido-4-Z-RR-AMC-methylcoumarin hydrochloride
C 5520 Z-Arg-Arg 4-methoxy-b-naphthylamide acetate salt
C 8536 Z-Ala-Arg-Arg 4-methoxy-b-naphthylamide acetate salt
H 2508 Hippuryl-Arg
S 6510 N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin
Cathepsin D
Enzymes
Prod No.: Product Name:
C 3138 Cathepsin D, Bovine
C 8696 Cathepsin D, Human
Inhibitors
A 6191 Antipain Hydrochloride
C 7268 Chymostatin
P 5318 Pepstatin A
Substrates
C 6358 N-Acetyl-Arg-Gly-Phe-Phe-Pro-7-amido-4-methylcoumarin *New
C 6983 N-Acetyl-Arg-Gly-Phe-Phe-Pro-7-amido-4-trifluoromethylcoumarin *New
M 0938 7-Methoxycoumarin-4-Acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys (DNP)-D-Arg-amide *New
Antibodies
C 0715 Anti-Cathepsin D
Cathepsin H
Enzymes
Prod No.: Product Name:
C 8821 Cathepsin H, Human Liver *New
Inhibitors
C 0408 Cystatin
K 1632 Kininogen
L 2023 Leupeptin Trifluoroacetate Salt
Substrates
A 2027 L-Arginine-7-amido-4-methylcoumarin hydrochloride
Cathepsin L
Enzymes
Prod No.: Product Name:
C 6854 Cathepsin L, Human Liver *New
Inhibitors
A 6185 N-Acetyl-Leu-Leu-Norleu-al
C 9109 Z-Phe-Phe-fluoromethyl keytone *New
C 9234 Z-Leu-Leu-Tyr-fluoromethyl ketone *New
C 9859 Z-Leu-Leu-Tyr-CHN2 *New
M 5314 N-Methoxysuccinyl-Phe-HOMO-Phe-fluoromethyl ketone *New
Substrates
C 3282 Z-Phe-Arg 4-methoxy-b-naphthylamide hydrochloride
Antibodies
C 2970 Monoclonal Anti-Cathepsin L

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