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Enzyme Explorer
Proteasome | ||
| Determine the fate of your protein. Explore the pathways of intracellular protein degradation with Sigma's comprehensive line of proteasome, calpain and lysosomal proteases. Overview of Ubiquitin and the Proteasome Pathway Product Guide: |
| Proteasome Pathway | ||
| Ubiquitination | ||
| Enzymes/Proteins | ||
| Prod No.: | Product Name: | |
| I 1154 | Isopeptidase T | *New |
| U 1633 | Ubiquitin Activating Enzyme, Yeast | *New |
| U 1758 | Ubiquitin Activating Enzyme, Rabbit | *New |
| U 2133 | Ubiquitin C-Terminal Hydrolase, L3 | *New |
| U 8382 | Ubiquitin conjugating enzyme fractions (mammalian) | *New |
| U 2633 | Ubiquitin Carrier Protein H2 / E2-14K | *New |
| U 2508 | Ubiquitin Carrier Protein H2 | *New |
| U 2383 | Ubiquitin Carrier Protein H3 | *New |
| U 8632 | Ubiquitin-Carrier Protein H5a, GST-tagged human | *New |
| U 8757 | Ubiquitin-Carrier Protein H5b human | *New |
| U 8882 | Ubiquitin-Carrier Protein H5c human | *New |
| U 9007 | Ubiquitin-Carrier Protein H6 human | *New |
| U 9132 | Ubiquitin-Carrier Protein H7 human | *New |
| U 9257 | Ubiquitin-Carrier Protein H9 human | *New |
| U 9382 | Ubiquitin-Carrier Protein H10 human | *New |
| U 5382 | Ubiquitin, human, recombinant, N-terminal FLAG-tagged | |
| U 5507 | Ubiquitin, human, recombinant, N-terminal his-tagged | |
| U 5632 | Ubiquitin-Agarose | |
| U 6253 | Ubiquitin from bovine erythrocytes | |
| U 8257 | Ubiquitin Fraction FI from HeLa cells | *New |
| U 8507 | Ubiquitin K48R | *New |
| Inhibitors | ||
| U 1507 | Ubiquitin Aldehyde | |
| U 1632 | Ubiquitin, Methylated | |
| Substrates | ||
| N 2030 | NEDD8 precursor (Pro NEDD8) | *New |
| N 8529 | NEDD8 | *New |
| S 0314 | SUMO-1/Sentrin-1 human | *New |
| S 0439 | SUMO-1/Sentrin-1 human | *New |
| U 5379 | Anti-Ubiquitin from rabbit | |
| U 2258 | Ubiquitin-AMC | *New |
| Proteasomes | ||
| Proteasome Fractions | ||
| Prod No.: | Product Name: | |
| F 3926 | Fraction II [FII] (HELA) | *New |
| F 4051 | Fraction II [FII] (Rabbit reticulocyte) | *New |
| P 3863 | 26S Proteasome Fraction from rabbit | *New |
| P 3988 | 20S proteasome (mammalian) | *New |
| P 4113 | S-100 proteasome fraction from HeLa cells | *New |
| Inhibitors | ||
| C 0358 | CBZ-Leu-Leu-Phe-Al | *New |
| C 2211 | N-CBZ-Leu-Leu-Leucinal | |
| C 6706 | N-CBZ-Leu-Leu-Norvalinal | |
| C 9857 | CBZ-Leu-Leu-Leu-B(OH)2 | *New |
| E 3652 | Epoxomicin | *New |
| E 3876 | N-Ethylmaleimide | |
| L 7035 | clasto-Lactacystin b-lactone | |
| L 6785 | Lactacystin | |
| G 9893 | Gliotoxin | |
| Substrates | ||
| C 0483 | Z-Leu-Leu-Glu-7-amido-4-methylcoumarin | *New |
| C 0608 | Z-Leu-Leu-Leu-7-amido-4-methylcoumarin | *New |
| C 0788 | CBZ-Leu-Leu-Glu-ß-naphthylamide | *New |
| Activator | ||
| P 5988 | PA28 activator (mammalian) | *New |
| Calpain | ||
| Enzymes | ||
| Prod No.: | Product Name: | |
| C 6108 | Calpain I | *New |
| P 4533 | Calpain II | |
| Inhibitors | ||
| A 6060 | N-acetyl-Leu-Leu-Methioninal | |
| A 6185 | Calpain Inhibitor I | |
| A 6191 | Antipain Hydrochloride | |
| C 4285 | Acetyl-Calpastatin (184-210) Human | |
| C 5913 | 4-Chloromercuribenzoic acid | |
| C 8984 | Z-Leu-Leu-Leu-fluoromethyl keytone | *New |
| C 9181 | Calpain Inhibitor Peptide | |
| C 9234 | Z-Leu-Leu-Tyr-fluoromethyl ketone | *New |
| C 9859 | Z-Leu-Leu-Tyr-CHN2 | *New |
| E 0514 | E-64c | |
| E 8640 | E-64d | |
| L 2023 | Leupeptin Trifluoroacetate salt | |
| M 5439 | N-Methoxysuccinyl-Val-HOMO-Phe-fluoromethyl ketone | *New |
| M 6159 | a2-Macroglobulin | |
| M 6690 | MDL 28170 (Calpain III inhibitor) | *New |
| Substrates | ||
| S 1153 | N-Succinyl-Leu-Tyr 7-amido-4-methylcoumarin | |
| S 6510 | Succinyl-Leu-Leu-Val-Tyr 7-amido-4-methylcoumarin | |
| Antibodies | ||
| C 0230 | Monoclonal Anti-m/5 Calpain, Small Subunit from mouse | *New |
| C 0355 | Monoclonal Anti-mu Calpain, Large Subunit, Clone 15C10, Mouse | *New |
| C-269 | Anti-Calpain (28 kDa subunit), monoclonal | |
| C 5361 | Anti-Mu-Calpain (Domain I) N-terminal | |
| C 5486 | Anti-Mu-Calpain (Domain I) | |
| C 5861 | Anti-Mu-Calpain (Domain I) N-terminal | |
| C-266 | Anti-mu-Calpain (Domain II), monoclonal | |
| C-267 | Anti-mu-Calpain (Domain II), monoclonal | |
| C 0728 | Anti-mu-Calpain Domain-III, large subunit | |
| C-268 | Anti-mu-Calpain (Domain III/IV), monoclonal | |
| C 6111 | Anti-M-Calpain (Domain III) | |
| C 0478 | Anti-LP-85 (lens-specific Calpain); Domain-IV, large subunit | |
| C 0603 | Anti-LP-82 (lens-specific Calpain)and LP-85; Domain-III, large subunit | |
| C 6611 | Anti-Calpain-94 (Domain I) | |
| C 6486 | Anti-Calpain-94 (Domain III) | |
| C 6361 | Anti-Calpain-94 (Domain II-Insert 1) | |
| C 6236 | Anti-Calpain-94 (Domain III-Insert 2) | |
| C 5611 | Anti-Mu-Calpain (Domain IV) | |
| C 5736 | Anti-Mu-Calpain (Domain IV) C-terminal | |
| C 5986 | Anti-Mu-Calpain (Domain IV) C-terminal | |
| C-270 | Anti-Calpastatin, monoclonal | |
| Lysosomal Proteases | ||
| Cathepsin B | ||
| Enzymes | ||
| Prod No.: | Product Name: | |
| C 6286 | Cathepsin B from bovine spleen | |
| C 8571 | Cathepsin B from human liver | |
| C 0150 | Cathepsin B from human placenta | |
| Inhibitors | ||
| A 6060 | N-Acetyl-Leu-Leu-Met-al | |
| A 6185 | N-Acetyl-Leu-Leu-Norleu-al | |
| A 6191 | Antipain Hydrochloride | |
| B 1932 | Biotin-Phe-Ala-fluoromethyl ketone | *New |
| C 0408 | Cystatin | |
| C 5732 | CA-074 | *New |
| C 5857 | CA-074 Methyl Ester | *New |
| C 7268 | Chymostatin | |
| C 8917 | Cystatin | |
| C 9109 | Z-Phe-Phe-fluoromethyl keytone | *New |
| E 3132 | E-64 | |
| L 2023 | Leupeptin Trifluoroacetate Salt | |
| M 5314 | N-Methoxysuccinyl-Phe-HOMO-Phe-fluoromethyl ketone | *New |
| M 6159 | a2-Macroglobulin | |
| P 0350 | Procathepsin B Fragment 26-50, rat | |
| P 0475 | Procathepsin B Fragment 36-50, rat | |
| Substrates | ||
| B 0885 | Na-Benzoyl-L-arginine 4-methoxy-ß-naphthylamide HCl | |
| C 2772 | Z-Val-Lys-Lys-Arg-4-methoxy-b-naphthylamide trihydrochloride | |
| C 3282 | Z-Phe-Arg 4-methoxy-b-naphthylamide hydrochloride | |
| C 5429 | Z-Arg-Arg-7-amido-4-Z-RR-AMC-methylcoumarin hydrochloride | |
| C 5520 | Z-Arg-Arg 4-methoxy-b-naphthylamide acetate salt | |
| C 8536 | Z-Ala-Arg-Arg 4-methoxy-b-naphthylamide acetate salt | |
| H 2508 | Hippuryl-Arg | |
| S 6510 | N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin | |
| Cathepsin D | ||
| Enzymes | ||
| Prod No.: | Product Name: | |
| C 3138 | Cathepsin D, Bovine | |
| C 8696 | Cathepsin D, Human | |
| Inhibitors | ||
| A 6191 | Antipain Hydrochloride | |
| C 7268 | Chymostatin | |
| P 5318 | Pepstatin A | |
| Substrates | ||
| C 6358 | N-Acetyl-Arg-Gly-Phe-Phe-Pro-7-amido-4-methylcoumarin | *New |
| C 6983 | N-Acetyl-Arg-Gly-Phe-Phe-Pro-7-amido-4-trifluoromethylcoumarin | *New |
| M 0938 | 7-Methoxycoumarin-4-Acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys (DNP)-D-Arg-amide | *New |
| Antibodies | ||
| C 0715 | Anti-Cathepsin D | |
| Cathepsin H | ||
| Enzymes | ||
| Prod No.: | Product Name: | |
| C 8821 | Cathepsin H, Human Liver | *New |
| Inhibitors | ||
| C 0408 | Cystatin | |
| K 1632 | Kininogen | |
| L 2023 | Leupeptin Trifluoroacetate Salt | |
| Substrates | ||
| A 2027 | L-Arginine-7-amido-4-methylcoumarin hydrochloride | |
| Cathepsin L | ||
| Enzymes | ||
| Prod No.: | Product Name: | |
| C 6854 | Cathepsin L, Human Liver | *New |
| Inhibitors | ||
| A 6185 | N-Acetyl-Leu-Leu-Norleu-al | |
| C 9109 | Z-Phe-Phe-fluoromethyl keytone | *New |
| C 9234 | Z-Leu-Leu-Tyr-fluoromethyl ketone | *New |
| C 9859 | Z-Leu-Leu-Tyr-CHN2 | *New |
| M 5314 | N-Methoxysuccinyl-Phe-HOMO-Phe-fluoromethyl ketone | *New |
| Substrates | ||
| C 3282 | Z-Phe-Arg 4-methoxy-b-naphthylamide hydrochloride | |
| Antibodies | ||
| C 2970 | Monoclonal Anti-Cathepsin L | |
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