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Enzyme Explorer

Molecular Parameters


Prealbumin, thyroxine-binding
Retinol-binding protein
Albumin
α-Globulins
β-Globulins
Apolipoproteins
γ-Mobility (non-immunoglobulin)
Complement Components
Coagulation Proteins
Cell-Related Plasma Proteins
Immunoglobulins (Antibodies)
Amyloid Proteins (Non-Immunoglobulin)
Misc. Trace Components

Plasma & Blood Protein Resource


Prealbumin, thyroxine-binding
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
Prealbumin, thyroxine-binding Human Noncovalent tetramer of identical chains AA 127 54,980 Gly 0
Retinol-binding protein back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
Retinol-binding protein Human Single chain AA 182 20,957 Glu 0
Albumin back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
Albumin Human Single chain AA 585 66,458 Asp 0
    Nucleic acid precursor NA 609 69,365   0
  Bovine Single chain AA 582 66,210 Asp 0
    Nucleic acid precursor NA 606      
  Porcine Single chain AA ~575 ~66,300 Asp 0
  Ovine Single chain AA 575 ~66,300 Asp 0
  Chicken Single chain AA 575 ~66,300 Asp 0
  Rat Single chain AA 584 64,600 Glu 0
    Nucleic acid precursor NA 608   Glu  
α-Globulins back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
α-Globulins              
α1-Microglobulin Human Single chain AA 167 26,000 Gly 20
α1-Acid glycoprotein Human Single chain AA 181 40,000 pGlu 42
  Rat Nucleic acid precursor NA 187 ~40,000 Gln +
α1-Antitrypsin Human Single chain AA 394 54,000 Glu 13
    Nucleic acid precursor NA        
  Baboon Nucleic acid precursor NA 394 ~54,000 Glu +
α1-Antichymortrypsin Human Single chain AA ~440 68,000 Asn 26
      NA 408      
α2-Antiplasmin Human Single chain AA   65,000 Asn 11
α1-Fetoprotein Human Nucleic acid precursor NA 590 66,300 Thr 3
  Rat Nucleic acid precursor NA        
  Mouse Nucleic acid precursor NA 586 72,000 Ala  
9.5 S α1-Glycoprotein
(serum amyloid P component) 		Human Two pentagons (10 non-covalently bound identical subunits) AA (182)10 ~250,000 His 13
α1B-Glycoprotein Human Possibly a single chain AA ~480 68,000 Ala 13
α1T-Glycoprotein Human Single chain   ~776 85,000   15
Vitamin D-binding protein
(Gc globulin) 		Human Single chain AA ~450 52,000 Leu 4
Thyroxine-binding protein Human Single chain     54,000   20
Inter-α-trypsin inhibitor Human Single chain AA   ~160,000 Lys 8
Ceruloplasmin Human Single chain (easily cleaved) AA 1,046 132,000 Lys 7
3.8 S Histidine-rich α2-glycoprotein Human Single chain AA ~440 ~58,500 Val 11
Galactoglycoprotein Human Single chain AA ~213 81,000 Blocked 76
3.1 S Leucine-rich α2-glycoprotein Human Single chaine AA 312 50,000 Val 23
α2µ-Globulin Rat (male) Nucleic acid precursor NA 162 18,709 Glu +
Zn-α2-Glycoprotein Human Single chain   ~258 41,000   18
α2HS-Glycoprotein Human Two chains (A & B) AA ~359 49,000 Ala 14
    B chain AA 27 3,386 Thr +
α2-macroglobulin Human 4 identical subunits AA 1,450 725,000 Ser 9.4
4S-α2,β1-Glycoprotein Human Single chain   ~465 60,000 Arg 28
Haptoglobin Human 2 pairs of nonidentical chains (αβ)2 AA 656 86,018 Val/Ile 16.4
    Single-chain precursor NA 245      
    α1 chain AA 83 9,189 Val 0
    α2 chain AA 142 15,939 Val 0
    β chain AA 245 33,820 Ile 19.4
    β chain NA        
  Canine One pair of chains (αβ) β chain AA        
Corticosteroid-binding globulin Human Single chain     52,000   30
8 S α3-Glycoprotein Human Tetramer     220,000   31
β-Globulins back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
Pregnancy-specific β1-glycoprotein Human A trimeric aggregate     (42,300)n   32.6
Transferrin Human Single chain AA 678 79,550 Val 5.9
      NA 679   Val  
Ovotransferrin Chicken Single chain AA 686 77,770 Ala +
    Nucleic acid precursor NA 686      
Hemopexin Human Single chain AA 439 60,000 Thr 22
  Rabbit Single chain AA ~440 57,000 Val 20
β2-Microglobulin Human Single chain AA 99 11,731 Ile 0
  Mouse Single chain AA 99   Ile 0
  Rabbit Single chain AA 99   Val 0
  Guinea pig Single chain AA 99   Val 0
C-Reactive protein Human Subunits aggregate as cyclic pentamers AA 187 (20,946)5 pGlu 0
  Rabbit Pentagonal structure AA 186   Ala 0
β2-Glycoprotein I Human Single chain AA 326 ~50,000 Gly 19
β2-Glycoprotein III Human Single chain, forms complex AA   35,000   10
Apolipoproteins back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
Apolipoprotein A-I (HDL) Human Single chain; no disulfides AA 243 28,076 Asp 0
Apolipoprotein A-II (HDL) Human Dimer of 2 identical chains, joined by disulfide AA 77 17,414 pGlu 0
Apolipoprotein C-I (VLDL) Human Single chain; no disulfides AA 57 6,631 Thr 0
Apolipoprotein C-II Human Single chain; no disulfides AA 78 8,829 Thr 0
Apolipoprotein C-III (VLDL) Human Single chain glycopeptide AA 79 8,764 Ser 3
Apolipoprotein E Human Single chain AA 299 34,183 Lys +
γ-Mobility (non-immunoglobulin) back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
0.6 S γ2-Globulin Human Single chain AA 47 5,100 Phe 0
2 S γ2-Globulin Human Single chain AA 132 14,000 Tyr 0
Basic Protein B2 Human Single chain AA ~85 9,000   0
Post-γ-Globulin (γ-trace) Human Single chain AA 120 13,248 Ser 0
Complement Components back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
C1q Human Six identical nocovalently-linked subunits, each with three similar chains (A,B&C) Total of 18 chains AA   410,000 Glu/Asn 9
    B chain AA 226   Glu +
    C chain AA ~200   Asn +
C1r Human Noncovalent dimer     (83,000)2   9.4
C1r Human B chain AA 242 27,096 Ile 12.4
C1s Human Single chain AA   83,000 Glu 7.1
C1s Human Two chains (a and b) AA   83,000 Glu/Ile 7.1
C2 Human Single chain AA   102,000 Ala +
C3 Human Two disulfide-bonded chains AA ~1,630 ~185,000   2
    α chain AA ~960 115,000 Ser  
    β chain AA ~670 75,000 Ser  
  Mouse ProcC3 is a single-chain precursor NA   ~190,000 Ile  
C3a Human Fragment of C3 a chain AA 77 9,093 Ser 0
  Porcine Fragment of C3 α chain AA 77 ~9,000 Ser  
  Rat Fragment of C3 α chain AA 78 ~9,000 Ser  
  Mouse Fragment of C3 α chain NA 78 ~9,800 Ser  
C4 Human Three disulfide-bonded chains AA     7  
    α chain AA ~785 93,000    
    β chain AA ~660 75,000    
    γ chain AA ~250 33,000    
C4a Human Fragment of a chain AA 77 8,763 Asn 0
  Bovine Fragment of a chain AA 77      
C5 Human Two disulfide-bonded chains     185,000   1.6
    α chain AA ~960 115,000 Thr  
    β chain   ~670 75,000    
C5a Human Fragment of α chain AA 74 8,274 Thr +
C6 Human Single chain AA ~900 1,048,000 Ala 3.8
C7 Human Single chain AA ~800 92,400 Ser 6.4
C8 Human Two noncovalently-linked subunits     163,000    
C4-Binding Protein Human Disulfide-bonded subunits (Mr 75,000)     540,000 Asn  
Factor D (C3 Proactivator Convertase) Human Single chain AA   24,000 Ile +
Factor B (C3 Proactivator) Human Single chain AA   90,000 Thr 6
    Bb Fragment AA 505 60,000 Lys +
Properdin Human Four non-covalent identical chains AA ~480 220,000 Asp 10
Factor H (β1H) Human Single chain AA ~1,275 155,000 Glu 9.3
C3b-Inactivator Human Two disulfide-bonded chains     90,000 Ile/Lys 11
    Light chain AA   40,000 Ile/Lys +
    Heavy chain AA   50,000 Lys +
Coagulation Proteins back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
Prothrombin Human Single chain AA 581 72,000 Ala 12
  Bovine Single chain AA 582 72,000 Ala 12
Thrombin Bovine Two disulfide-linked chains AA ~340 37,000 Thre/ILE  
    A chain AA 49 5,728 Thre/ILE 0
    B chain AA 259 31,000 Ile  
FactorVII Human Single chain (two chains when activated) AA   48,000 Ala 16
Factor VIII Human Noncovalent complex     (100,000)n   6
Factor IX Human Single chain Precursor NA 462 51,801   +
  Bovine Single chain AA 427 ~55,000 Tyr 26
Factor IXa (activated) Human Heavy and light chains NA 381      
    Light chain NA 145   Tyr  
    Heavy chain AA 236   Val  
  Bovine Heavy and light chains AA 390 ~46,500 Tyr/Val 11
    Light chain AA 146 16,600 Tyr 7.4
    Heavy chain AA 232 27,300 Val 13
Factor X Human Heavy and light chains AA   59,000 Ala/Ser 15
    Light chain AA 139 16,211 Ala/Ser 0
  Bovine Heavy and light chains AA 447 55,000 Trp/Ala 10
    Light chain AA 140 16,143 Ala/Ser 0
    Heavy chain AA 307 38,000 Trp/Ala 11.5
Factor Xa Activated Bovine Heavy and light chains AA 396 44,000 Ile/Ala 3
    Light chain AA 140 16,000 Ala 0
    Heavy chain AA 256 28,000 Ile 0
Factor XI Human Two idenical disulfide-linked chains AA   130,000 Gly 5
Protein C Bovine Two disulfide-linked chains AA 415 55,000 Ala/Asp 14
    Light chain AA 155 21,000 Ala +
    Heavy chain AA 260 35,000 Asp +
Protein S Human Single chain AA   ~69,000 Ala 7.8
  Bovine   AA   ~66,000 Ala +
Protein Z Bovine Single chain AA   ~50,000 Ala +
Fibrinogen Human Three pairs of disulfide bonded chains AA 2,964 340,000   4
    α chain AA 610 64,115 Ala  
    β chain AA 461 52,314 Gln +
    γ chain AA 411 46,468 Tyr +
Plasminogen Human Single chain AA 790 ~92,000 Glu 1.5
Plasmin   Two-chain after activation   790   Glu/Val 1.5
    Heavy chain (A)   560   Glu +
    Light chain (B)   230   Val 0
Factor XII Human Single chain AA   76,000 Ile 17
Factor XIII (Transglutaminase)   Two pairs of non-identical chains (a2b2) AA   320,000   4.9
HMW and LMW Prekininogens Bovine Single chain Precursor NA 621      
LMW Kininogen Bovine Heavy chain AA 361   (Thr) +
    Light chain   47   Ser  
               
Antithrombin III Human Single chain AA 430 58,000 His 15
Cell-Related Plasma Proteins back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
Fibronectin Human Disulfide-linked Dimer AA ~1,900 ~440,000 pGlu +
  Human Disulfide-linked Dimer AA ~1,880 ~440,000 pGlu +
β-Thromboglobulin Human Tetramer of identical chains AA 81 35,404 Gly 0
Platelet Factor-4 Human Tetramer of identical chains AA 70 (7,769)4 Glu 0
Serum Basic Protease Inhibitor Bovine Single chain AA 60 6,647 Thr 0
Immunoglobulins (Antibodies) back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
Immunoglobulins (Antibodies) Higher Vertebrates Four disulfide-bonded chains, two heavy and two light     (160,000)n   Varies
κ or λ Light Chains (Bence Jones Proteins) Human Monomer of dimer AA ~214 ~23,000 Varies 0
  Human Kappa (κ) AA ~214 ~23,500 Varies 0
    Lambda (λ) AA ~214 ~23,000 Varies 0
Immunoglobulin G (IgG) Human (γκ)2 or (γλ)2 monomer     ~ 150,000 Varies 3
   IgG1   γ1 Heavy chain AA ~475 ~50,000 Varies +
   IgG2   γ2 Heavy chain AA ~450 ~50,000 Varies +
   IgG3   γ3 Heavy chain AA ~475 ~55,000 Varies +
   IgG4   γ4 Heavy chain AA ~450 ~50,000 Varies +
Immunoglobulin A (IgA) Human (α2κ2)n or (α2λ2)n n=1,2 or 4     ~(160,000)n Varies 8
   IgA1   α1 Heavy chain AA ~475 ~60,000 Varies +
   IgA2   α2 Heavy chain AA ~450 ~60,000 Varies +
Immunoglobulin M (IgM) Human µ2κ2 or µ2λ2 monomer     ~950,000 Varies 10
    µ Heavy chain AA ~575 ~75,000 Varies +
Immunoglobulin D (IgE) Human δ2κ2 or δ2λ2 monomer   ~510 ~175,000 Varies 9
    δ Heavy chain AA   ~65,000 Varies +
Immunoglobulin E (IgE) Human σ2κ2 or σ2λ2 monomer     ~190,000 Varies 12
    σ Heavy chain AA ~550 ~72,000 Varies +
J Chain Human Single chain AA 129 14,619 pGlu  
    Single chain Precursor NA 137      
Amyloid Proteins (Non-Immunoglobulin) back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
Amyloid-Related Apoprotein (apoSAA1) Human Single chain Precursor AA 104 11,683 Arg 0
AA (FMF) (ASF) Human Single chain Precursor AA 76 9,150 Arg 0
AA (TH) (AS) Human Single chain Precursor AA 76 9,145 Arg 0
Serum Amyloid P Component (9.5 S 7α1-glycoprotein) Human Ten Subunits aggregates as two pentamers AA ~184 ~25,000 His 13
Misc. Trace Components back to top
Protein Species Subunit Structure Method Chain Length Protein MW Amino Terminus Carb. Content (%)
Carcinoembryonic Antigen Human   AA         +
Angiotensinogen Human   AA       Asp  
  Rat Single chain Precursor NA 453 49,548 Asp (+)

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A special thanks to Frank Putnam for allowing us to replicate information referenced from "The Plasma Proteins", Volume IV, 2nd Edition, 1984, Frank W. Putnam.
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