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Enzyme Explorer
Plasma Protein Composition
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Plasma & Blood Protein Resource
| Protein |
Symbol |
Molecular Weight |
Amount in Normal Serum (plasma) (mg/100ml) |
Carbohydrate Content (%) |
| Prealbumin, thyroxine-binding |
TBPA |
54,980 |
10-40 |
0 |
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|
| Retinol-binding protein |
RBP |
21,000 |
3-6 |
0 |
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| Albumin |
Alb |
66,500 |
3,500 - 5,000 |
0 |
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|
| Galactoglycoprotein |
GGP |
81,000 |
– |
76 |
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| α-Globulins |
|
|
|
|
| α1-Acid glycoprotein |
α1S |
40,000 |
55-140 |
42 |
| α1-Antitrypsin |
α1AT |
54,000 |
200-400 |
13 |
| α1-Fetoprotein |
α1F |
66,300 |
~1µg |
3 |
| 9.5 S α1-Glycoprotein (serum amyloid P protein) |
α1M, SAP |
~250,000 |
3-8 |
13 |
| GC Globulin |
Gc |
52,000 |
20-55 |
4 |
| Ceruloplasmin |
Cp |
132,000 |
15-60 |
7 |
| 3.8 S Histidine-rich α2-glycoprotein |
HRG |
58,500 |
5-15 |
11 |
| α2-Macroglobulin |
α2M |
725,000 |
150-420 |
9.4 |
| 4 S α2, β1-Glycoprotein |
– |
60,000 |
Trace |
28 |
| α1B-Glycoprotein |
α1B |
68,000 |
15-30 |
13 |
| α1T-Glycoprotein |
α1T |
85,000 |
5-12 |
15 |
| α1-Antichymotrypsin |
α1X |
68,000 |
30-60 |
26 |
| α1-Microglobulin |
α1m |
26,000 |
4-9 |
20 |
| Zn-α2-Glycoprotein |
Znα2 |
41,000 |
2-15 |
18 |
| α2HS-Glycoprotein |
α2HS |
49,000 |
40-85 |
14 |
| Pregnancy-associated α2-glycoprotein |
α2PAG |
360,000 |
Trace |
|
| 3.1 S Leucine-rich α2-glycoprotein |
LRG |
49,600 |
2-3 |
23 |
| 8 S α3-Glycoprotein |
8Sα3 |
220,000 |
3-5 |
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| Serum cholinesterase |
CE |
348,000 |
0.5-1.5 |
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| Thyroxine-binding globulin |
TBG |
54,000 |
1-2 |
20 |
| Inter-α-trypsin inhibitor |
IαI |
~160,000 |
20-70 |
8 |
| Transcortin |
TC |
55,700 |
~7 |
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| Haptoglobin |
Hp |
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16.4 |
| Type 1-1 |
– |
86,000 |
100-220 |
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| Type 2-1 |
– |
~200,000 |
160-300 |
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| Type 2-2 |
– |
~400,000 |
120-260 |
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| β-Globulins |
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|
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| Hemopexin |
Hpx |
60,000 |
50-115 |
22 |
| Transferrin |
Tf |
79,500 |
200-320 |
5.9 |
| β2-Microglobulin |
β2m |
11,730 |
Trace |
0 |
| β2-Glycoprotein I |
β2I |
~48,000 |
15-30 |
19 |
| β2-Glycoprotein II |
GGG |
63,000 |
12-30 |
10 |
| (C3 proactivator) |
C3PA |
– |
– |
– |
| β2-Glycoprotein III |
β2III |
35,000 |
5-15 |
10 |
| C-Reactive Protein |
CRP |
105,000 |
<1 |
0 |
| Fibronectin |
Fn |
440,000 |
25-40 |
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| Low-molecular weight proteins |
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| Lysozyme |
|
14,000 |
0.5-1.5 |
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| Basic protein B1 |
B1 |
11,000 |
– |
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| Basic protein B2 |
B2 |
8,800 |
<1 |
0 |
| 0.6 S γ2-Globulin |
– |
5,100 |
<1 |
0 |
| 2 S γ2-Globulin |
– |
14,000 |
0.1 |
0 |
| Post γ-globulin |
Pγ |
13,260 |
– |
0 |
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|
| Complement components |
C |
|
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| C1q Component |
C1q |
400,000 |
10-25 |
9 |
| C1r Component |
C1r |
166,000 |
– |
9.4 |
| C1s Component |
C1s |
83,000 |
1-2 |
7.1 |
| C2 Component |
C2 |
102,000 |
2-3 |
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| C3 Component |
C3 |
185,000 |
55-120 |
2 |
| C4 Component |
C4 |
200,000 |
20-50 |
7 |
| C5 Component |
C5 |
185,000 |
4-15 |
1.6 |
| C6 Component |
C6 |
105,000 |
7 |
3.8 |
| C7 Component |
C7 |
92,500 |
6 |
6.4 |
| C8 Component |
C8 |
163,000 |
8 |
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| C9 Component |
C9 |
71,000 |
23 |
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| Other complement factors |
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| C1 Esterase inhibitor |
C1-INA |
104,000 |
15-35 |
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| Factor B |
B |
90,000 |
– |
6 |
| Factor D |
D |
24,000 |
– |
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| Factor H |
H |
155,000 |
– |
9.3 |
| C4 Binding Protein |
C4bp |
540,000 |
– |
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| Properdin |
P |
220,000 |
2-3 |
10 |
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| Coagulation proteins |
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| Antithrombin III |
ATIII |
58,000 |
(20-40) |
15 |
| Prothrombin |
FII |
72,000 |
(5-10) |
12 |
| Antihemophilic factor (Factor VIII) |
AHF, FVIII |
(100,000)n |
(1-2) |
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| Plasminogen |
Pmg |
92,000 |
(6-25) |
1.5 |
| Fibrin-stabilizing factor (Factor XIII) |
FXIII |
320,000 |
(1-4) |
4.9 |
| Fibrinogen |
F1 |
340,000 |
200-450 |
4 |
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| Immunoglobulins |
Ig |
|
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| Immunoglobulin G |
IgG |
150,000 |
800-1800 |
3 |
| Immunoglobulin A |
IgA |
(160,000)n |
90-450 |
8 |
| Immunoglobulin M |
IgM |
950,000 |
60-250 |
10 |
| Immunoglobulin D |
IgD |
175,000 |
<15 |
9 |
| Immunoglobulin E |
IgE |
190,000 |
<0.06 |
9 |
| κ Bence Jones protein |
κBJP |
23,000 |
Trace |
0 |
| γ Bence Jones protein |
γBJP |
23,000 |
Trace |
0 |
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A special thanks to Frank Putnam for allowing us to replicate information referenced from "The Plasma Proteins", Volume IV, 2nd Edition, 1984, Frank W. Putnam.
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