Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Structural Proteins

Actinin

α-Actinin is an actin-binding protein present in both muscle and non-muscle cells. It has a polypeptide molecular weight of 100 kD and forms dimers in solution. In normal skeletal muscle, α-actinin is associated with the Z-discs that define the muscle sarcomers. In smooth muscle, α-actinin is detected predominantly in dense bodies and plaques, which are characteristic of that tissue. Immunofluorescent labeling of a large variety of cells with anti α-actinin reveals an extensive association of the proteins with the actin containing stress fibers and, in particular, with their membrane-bound termini.

Actinin Products

back to Structural Proteins