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Keratin is the primary fibrous structural protein component of hair, skin and nails. Keratin intermediate filaments are also a cytoskeletal component of desmosome cellular junctions. Keratins are highly cross-linked proteins typically containing α-helix and β-sheet motifs and are high in glycine and alanine content. Typically keratin exists as a heterodimeric paring of Type I, low MW acidic peptides and Type II high MW, neutral or basic peptides. At least 30 different genes code for keratin proteins.
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