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Metabolomics
IUBMB Nicholson Minimaps | ||
  © 2003 IUBMB |
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Over the past 40 years, 21 editions and over a million Metabolic Pathways Charts have sought to provide a unique picture of integrated metabolism. These are now supplemented by Minimaps which take selected individual pathways and enlarge them to illustrate aspects of metabolism that could not previously be shown — such as compartmentation, enzymes and regulation. By the use of different-coloured backgrounds to identify different organs and organelles and tissues and membranes it becomes possible to show how often opposing reactions (as in biosynthesis and degradation) can both take place in the same cell. The pathways are designed to "flow" from a highlighted starting point to a highlighted ultimate product - a process which in relevant cases is clarified by the judicious use of blood vessels. The object is to make the pathways easy to explore, meaningful, and fun. Real-life Metabolism!
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Select a minimap from the list below, each of which is available in two versions: GIF or PDF. The PDFs are best viewed with Acrobat version 4 or higher. Free PDF plugin may be downloaded from Adobe's Web site. To view GIFs of the Minimaps below, please click here. |
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| Title | |
| 1. The Hub of Metabolism | PDF (52 kb) |
| 2. Glycolysis | PDF (44 kb) |
| 3. Lactic and Alcoholic Fermentation | PDF (240 kb) |
| 4. Glycolysis and TCA Cycle - Reactions | PDF (52 kb) |
| 5. Glycolysis and TCA Cycle - Products of Potential Energy | PDF (54 kb) |
| 6. Glycolysis and TCA Cycle - Enzymes and EC Reference Numbers | PDF (62 kb) |
| 7. Glycolysis and TCA Cycle - Compartmentation | PDF (53 kb) |
| 8. Glycolysis and TCA Cycle - Compartmentation (Simplified) | PDF (49 kb) |
| 9. Glycolysis and TCA Cycle - Shuttles | PDF (70 kb) |
| 10. Glycolysis and TCA Cycle - Regulation | PDF (58 kb) |
| 11. Mitochondrial ATP Formation | PDF (640 kb) |
| 12. ATP Yield | PDF (636 kb) |
| 13. Anaplerotic (Replenishing) Reactions of the TCA Cycle | PDF (61 kb) |
| 14. The Glyoxylate Pathway | PDF (65 kb) |
| 15. Gluconeogenesis and Glycolysis | PDF (143 kb) |
| 16. Gluconeogenesis and Glycolysis - Regulation | PDF (133 kb) |
| 17. Lipid Metabolism | PDF (112 kb) |
| 18. Deamination of Amino Acids - The Urea Cycle | PDF (87 kb) |
| 19. Purine Metabolism | PDF (98 kb) |
| 20. Pyrimidine Metabolism | PDF (104 kb) |
| 21. Pentose Phosphate Pathways | PDF (73 kb) |
| 22. Pentose Phosphate Pathways - Pathway II | PDF (70 kb) |
| 23. Photosynthesis in the Chloroplast | PDF (631 kb) |
| 24. Photosynthesis - Regulation | PDF (461 kb) |
| 25. Night-Life in the Chloroplast | PDF (590 kb) |
| 26. Basic Photosynthesis | PDF (489 kb) |
| 27. Photosynthesis - Calvin Cycle | PDF (119 kb) |
| 28. Folic Acid Metabolism | PDF (66 kb) |
| 29. Folic Acid Reactions | PDF (63 kb) |
| 30. Folic Acid and Early Chemotherapy | PDF (181 kb) |
| 31. Isoprene Metabolism | PDF (88 kb) |
| 32. Products of Isoprene Metabolism | PDF (143 kb) |
| 33. Heme Metabolism | PDF (123 kb) |
| 34. Prostaglandins | PDF (245 kb) |
| 35. ATP and Histidine Interrelationships | PDF (75 kb) |
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Acknowledgments I would like to acknowledge with gratitude the many biochemists who have encouraged, guided, and positively criticised these creations. They include many colleagues in the School of Biochemistry & Molecular Biology at Leeds, especially Ed Wood. Martin Brand at Cambridge and Malcolm Watford at Rutgers have constantly and patiently offered their expertise to enhance the accuracy and clarity of some of the trickiest and most important of the maps. The Nomenclature Committee of the IUBMB has official oversight of the maps and some of their busiest members have spent untold hours assessing and correcting my numerous biochemical and typographical errors. To Hal Dixon at Kings College Cambridge, to Dick Cammack at Kings College London and to Keith Tipton at Trinity College Dublin, I am especially grateful. Donald Nicholson |
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