Epigenetics

Sigma has a wide portfolio of products to support Epigenetics research. The is a rapid method to determine the methylation status of CpG islands. Sigma also has products to study Histone modification, including transcription regulators such as anti-histone antibodies.

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<  Imprint® Methylated DNA Quantification technology A rapid and reliable method to measure global DNA methylation shifts in about half of a day. Fast - The total protocol can be completed in about 4 hours Flexible - 8 well assay strips may be used for high-throughput applications or manual analysis; genomic DNA from cultured cells, tissues, plasma, or other body fluid samples may be used Convenient - This simple protocol uses a familiar ELISA-like procedure:  colorimetric quantification and no radioactivity; low DNA input from 10-200 ng Complete - Includes methylated control DNA and all necessary reagents except water Sensitive - Detection limit is 5 ng of fully methylated genomic DNA (we used human in our tests).