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Kits for Epigenetics

Epigenetics describes gene expression changes that are stable, but potentially reversible, that occur without permanent changes in DNA sequence and in some cases are heritable. Many types of epigenetic processes have been identified including DNA methylation and chromatin remodeling.

Sigma-Aldrich has developed easy-to-use kits to study epigenetic processes. Our product line includes kits to study histone modifications (acetylation and deacetylation) and DNA methylation. We also offer select immunopreciptation kits to study the interactions between proteins and nucleic acids (DNA and RNA). Each kit contains a detailed protocol and provides sensitive results in a rapid manner. Most reagents are included. Please refer to the technical bulletin or kit specific webpage for additional required reagents.

In addition to kits, Sigma-Aldrich also offers a collection of inhibitors and activators to aid in epigentic studies.

Acetylation and Decacetylation Assays

Product #

Description

Add to Cart

EPI001 Histone Acetyltransferase (HAT) Activity Assay Kit 100 assays in 96 well plates
CS1010 Histone Deacetylase Assay Kit, Fluorometric sufficient for 100 assays (96 well plates)
EPI004 Histone Deacetylase 3 (HDAC3) Activity Assay Kit 100 assays in 96 well plates
EPI005 Histone Deacetylase 3 (HDAC3) Inhibitor Screening Kit 100 assays in 96 well plates
EPI006 Histone Deacetylase 8 (HDAC8) Activity Assay Kit 100 assays in 96 well plates
EPI007 Histone Deacetylase 8 (HDAC8) Inhibitor Screening Kit 100 assays in 96 well plates
EPI003 In Situ Histone Deacetylase (HDAC) Activity Fluorometric Assay Kit 100 assays in 96 well plates
CS1040 SIRT1 Assay Kit sufficient for 100 assays
EPI010 Sirtuin 2 (SIRT2) Inhibitor Screening Assay Kit 100 assays in 96 well plates

DNA Methylation Analysis

Product #

Description

Add to Cart

MOD50 Imprint® DNA Modification Kit For bisulfite DNA conversion & purification
MDQ1 Imprint® Methylated DNA Quantification Kit To measure global DNA methylation shifts from as low as 10 ng DNA

Select Immunoprecipation Kits for Epigenetics

Product #

Description

Add to Cart

CHP1 Imprint® Chromatin Immunoprecipitation Kit Complete ChIP reaction in 6 hours in flexible strip well format
RIP Imprint® RNA Immunoprecipitation Kit High-capacity Protein A magnetic beads for successful RNA Immunoprecipitation,

suitable for use with mRNA and microRNA
CHP2 Imprint® Ultra Chromatin Immunoprecipitation Kit Complete ChIP kit for sensitivity, compatibility with Next-Gen sequencing
CHP2NC Imprint® Ultra Chromatin Immunoprecipitation Kit, Without Controls ChIP kit for maximum sensitivity, compatible with Next-Gen sequencing
CHROP Imprint® Ultra Chromatin Optimization Kit Kit designed to optimize sonication parameters for ChIP experiments