Certain features of will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Histone Deacetylase Inhibitors

Histone deacetylases (HDACs) are enzymes that remove acetyl groups from lysines of histones and a number of other regulatory and structural proteins. They play critical roles in chromatin remodeling and are involved in transcription regulation, cell-cycle progression, cell survival and differentiation. So far, 18 HDACs have been identified and divided into 3 distinct enzyme classes.
Class I and II HDACs are zinc dependent. Class I, homologous to yeast Rpd3, includes HDAC1, 2, 3, and 8. Class II (HDAC4, 5, 6, 7, 9, 10) resembles yeast Hda1. Class I and II HDACs are associated with malignant transformations and are targets for cancer drugs. Inhibitors of Class I and II HDACs are largely classified into four groups on the basis of their chemical structures.