Nucleoside analog inhibitors

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A2385 5-Azacytidine ≥98% (HPLC) A potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression, gene activation and silencing.
Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes.
human ... DNMT1(1786), DNMT3A(1788), DNMT3B(1789)
Z4775 Zebularine ≥98% (HPLC), solid Zebularine is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.