Histone Lysine Methyltransferase (HKMT) Inhibitors

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B9311 BIX 01294 trihydrochloride hydrate ≥98% (HPLC), powder BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro.
 
C9492 Chaetocin from Chaetomium minutum ≥95% (HPLC) Antibacterial mycotoxin. Specific inhibitor of lysine-specific histone methyltransferase making the compound useful in the study of heterochromatin mediated gene repression. Selective competitive inhibitor of thioredoxin reductase-1 (TrxR1), a putative mechanism of its anticancer activity.
methyltransferase making the compound useful in the study of heterochromatin mediated gene repression. Selective competitive inhibitor of thioredoxin reductase-1 (TrxR1), a putative mechanism of its anticancer activity.