Gangliosides

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialylated polysaccharide chain linked to ceramide through a ß-glycosidic linkage.
For more information on Glycosphingolipids Gangliosides please browse our online Glycobiology Analysis Manual.

Product #

Description

Biochem/physiol Actions

CAS Number

Add to Cart

G3018 Asialoganglioside GM1 from bovine brain ~98%, lyophilized powder Removing the sialic acid from monosialoganglioside GM1 inhibits its ability to bind cholera toxin. Asialoganglioside GM1 does not block the binding of cholera toxin to cellular GM1.
71012-19-6
G9398 Asialoganglioside-GM2 from bovine brain ~95%, lyophilized powder Degraded form of Asialoganglioside-GM1 ganglioside.
35960-33-9
G2392 Disialoganglioside GD1a from bovine brain ≥95% (TLC), lyophilized powder The major ganglioside in brain. Converted to GM1 by bacterial and mammalian sialidase. Differentiation marker for cell growth.
12707-58-3
G8146 Disialoganglioside GD1b from bovine brain ~95%, lyophilized powder May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.
19553-76-5
G0776 Disialoganglioside-GD2 from bovine brain ~95%, lyophilized powder, semisynthetic Cell surface component from disialoganglioside-GD1b.
65988-71-8
345736 Ganglioside GD1a, Disialo, Diammonium Salt, Bovine Brain - Calbiochem Useful as a differentiation marker of tumor cell growth.    
345742 Ganglioside GD1b, Disialo, Human Brain - Calbiochem Gangliosides are highly purified sialic acid-containing glycolipids that are used as markers of various cell types and antigens.    
345743 Ganglioside GD₂, Disialo, Human Brain - CAS 65988-71-8 - Calbiochem Ganglioside GD₂, Disialo, Human Brain, CAS 65988-71-8, is a highly purified sialic acid-containing glycolipids that is useful as markers of various cell types and antigens.   65988-71-8
345752 Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk Has been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma.    
345724 Ganglioside GM₁, Ammonium Salt, Bovine Brain - CAS 37758-47-7 - Calbiochem Monosialoganglioside extracted from bovine brain.   37758-47-7
345747 Ganglioside GM₁, Asialo, Human Brain - CAS 71012-19-6 - Calbiochem Gangliosides are highly purified sialic acid-containing glycolipids that are useful as markers of various cell types and antigens.   71012-19-6
345733-M Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem Contains mainly N-acetylneuraminic acid.    
345748 Ganglioside GM₄, Monosialo, Human Brain - Calbiochem Gangliosides are highly purified sialic acid-containing glycolipids that are useful as markers of various cell types and antigens.    
345754 Ganglioside GQ1b, Tetrasialo, Tetraammonium Salt, Bovine Brain - Calbiochem Ganglioside GQ1b enhances spontaneous IgG, IgM, and IgA production in human peripheral monocytic cells.    
345744 Ganglioside GT1b, Trisialo, Triammonium Salt, Bovine Brain - Calbiochem Inhibits Con A-stimulated mitogenesis in murine T cells.    
G5660 Lysoganglioside-GM1 from bovine brain ≥95%, lyophilized powder Suggested to be a modulator of cell growth and signal transduction. Accumulates in the nervous system of patients with GM1 gangliosidosis. Used for the preparation of GM1 derivatives containing different fatty acids, fluorescent tags, or other residues.
171483-40-2
G7641 Monosialoganglioside GM1 from bovine brain ≥95%, lyophilized powder   37758-47-7
G9652 Monosialoganglioside GM1 from bovine brain lyophilized powder, BioXtra, γ-irradiated, ≥95% (TLC) Monosialoganglioside GM1 is a major sialoglycolipid of neuronal membranes that modulates calcium homeostasis. It binds to cholera toxin B subunit, resulting in stimulation of adenylate cyclase in a wide variety of cell types. After cholera toxin binds to membrane associated monosialoganglioside GM1, the A subunit of cholera toxin is translocated to the cell interior, where it catalyzes the ADP ribosylation of the membrane associated Gs subunit of adenylate cyclase. In addition, binding of cholera toxin to monosialoganglioside GM1 causes translocation of NF-κB and activation of dendritic cells.

Monosialoganglioside GM1 was one of many mono- and oligosaccharide ligands studied for their affinity for NKR-P1, a membrane protein on natural killer cells, which contains an extracellular Ca2+-dependent lectin domain. Monosialoganglioside GM1 is effective in partially correcting the consequences of neuroinjury in a number of in vivo and in vitro model systems.
37758-47-7
G8397 Monosialoganglioside GM2 from bovine brain ≥95% (TLC) Minor component of cell membranes that has been shown to accumulate in Tay-Sachs disease.
19600-01-2
G5642 Monosialoganglioside GM3 from canine blood ≥98%, lyophilized powder Monosialoganglioside-GM3 is the most common ganglioside and the major ganglioside in non-neuronal cell membranes. It inhibits epidermal cell growth and is involved in the biosynthesis and metabolism of all higher gangliosides.
54827-14-4
G3767 Trisialoganglioside-GT1b from bovine brain lyophilized powder, ≥96% (TLC) Ganglioside marker for metastatic brain tumors. Modulates cellular differentiation; prevents glutamate neurotoxicity; inhibits mitogenesis stimulated by lectins such as Con A. Converted to GD1b by bacterial and mammalian sialidases.
59247-13-1