Nucleic Acid Chemistry

Proligo® Custom Products


 

Our Hamburg manufacturing site provides exclusive partnerships for custom projects. Non-catalog items are manufactured upon request with predefined cost targets and specifications. Services include scale-up of laboratory products from grams to kilograms, process development and analytical method development. Our team of dedicated specialists and process engineers ensure timely delivery of high quality products. Projects are handled with strict confidentiality.

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Types of Custom Products
 

Nucleoside Phosphoramidites:

  • Alternative protective group patterns
  • Nucleobase modifications
  • Backbone modifications
 

Modifiers:

  • Linker phosphoramidites
  • Spacer phosphoramidites
  • Reporter phosphoramidites
     

Soild Support Materials:

  • Loaded with unusual bases
  • Alternative linkages
  • CPG and organic polymers
 

Liquid Reagents:

  • Custom blends
  • Custom Fittings

 

Packaging and Filling Operations

The Hamburg manufacturing facility can handle the following packaging services:

 

Powders:

  • Automated powder filling line
  • Synthesis column assembly
  • Custom packaging - mg to Kg
 

Liquids:

  • Glass bottle & drum packaging
  • Explosion proof manufacturing environment
  • Separated areas for filling and packaging
  • Custom packaging on demand
     

Standard Bottles and Characteristics
 

Septum Bottles

Description Height (cm) Diameter (cm) Quantity (powder) Use at Synthesizer
Appearance
7mL septum 3.8 2 0.1 mmol ABI® 7 ml septum bottle
15mL septum 4.5 2.9 0.25g, 0.5g, 1g ABI 15 ml septum bottle
60mL septum 10.0 3.3 1g, 2g, 4g ABI 60 ml septum bottle
100mL septum 9.5 5.1 5g, 10g ABI, ÄKTA® , OligoPilot® 100ml septum bottle

Screw Cap Bottles

Description Height (cm) Diameter (cm) Quantity (powder) Quantity (liquid reagents) Use at Synthesizer Appearance
 1oz 20/400 (30 mL) 7.8 3.1 0.25 g, 0.5 g, 1 g   Expedite™, PolyGen® 1 oz 20/400 (30ml) screw cap bottle
 2oz 20/400 (60 mL) 9.4 3.8 1g, 2g   Expedite, PolyGen 2oz/60ml screw cap bottle
 1oz 28/400 (30ml) 3.5 6.6 0.5 g, 1 g   MerMade 1oz / 30ml screw cap bottle
 8oz 28/400 (240 mL) 13.7 6 5 g, 10 g 200mL Expedite, PolyGen, ABI®, MerMade 8oz / 240 ml screw cap bottle
 8oz 24/400 (240 mL) 13.7 6 10g 180 mL, 200 mL ABI 39X, ABI 3400 8oz / 240ml screw cap bottle
 16oz 28/400 (480 mL) 17.0 7.2 10g, 20g 450 mL Expedite, PolyGen, ABI®, MerMade 16oz / 480ml screw cap bottle
 1g CPG bottle (10 mL) 5.8 2.5 1g     1g / 10ml screw cap bottle
 10g CPG bottle (50 mL) 9.5 4 10g     10 g / 50ml screw cap bottle
 32 oz 28/400 (960mL) 21.0 9.4   900mL Expedite, ABI 32oz / 960ml screw cap bottle
 1L GL45 21.2 16.1 10 g, 40g
1L   1L screw cap bottle
 2.5L 28/400 31.0 13.5   2L Expedite, ABI 2.5L screw cap bottle
 2.5 L GL45 29.6 13.5   2.5L ÄKTA, OligoPilot, Expedite, ABI 2.5L screw cap bottle
 4 L 38/430 35.3 16.1   4L ÄKTA, OligoPilot, Expedite, ABI 4L screw cap bottle

Packing on Demand

different packing optionsWe pack products to fit virtually any synthesizer requirement, including ABI™ 394, ABI 3900, Expedite™, ÄKTA® and MerMade and custom packaging.

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Returnable Drums (Stainless Steel)

Description Weight (kg) Height (mm) Diameter (mm) Wall Thickness (mm)
Material Closure Operating Pressure Approval Number Appearance
18L with dip tube
6.6 442 278 1.5 V2A 1.4301 SS304 Screw cap DIN 11851 PTFE R52x1/6” 0.5 bar 1A1/X2,0/900 18L Returnable Drum with dip tube
25L with dip tube
10 400 380 1.5 1.4301 3A Coding MAV Micro Matic Valve 0.5 bar 1A1/X2,3/900 25L Returnable Drum with Dip Tube
45L with dip tube
11 600 363 1.5 V2A 1.4301 SS304 Screw cap DIN 11851 PTFE R52x1/6” 0.5 bar 1A1/X2,3/900 45L Returnable Drum with Dip Tube
45L with dip tube 12 600 263 1.5 1.4301 4F Coding MAV Micro Matic Valve 0.5 bar 1A1/X2,3/900 45 L Returnable Drum with Dip Tube
200L with level sensor & dip tube
43 970 600 2 1.4301 On Demand 0.5 bar 1A1W/X2,0/900 200L Returnable Drum with Level Sensor and Dip Tube
200L with dip tube 43 970 600 2 1.4301 Screw cap DIN 11851 PTFE R52x1/6” 0.5 bar 1A1W/X2,0/900 200L Returnable Drum with Dip Tube
1400L with dip tube
247 1960 1200   1.4301 On Demand 0.5 bar 31A/Y 1400 Returnable Drum with Dip Tube

Disposable Drums (Sheet Steel)

Description Weight (kg) Height (mm) Diameter (mm) Wall Thickness (mm)
Material Closure Approval Number Appearance
25L
3.4 560 280 0.5 PE-HD A BCS 56x4 (1x) 1A1/X1,6/250 25L Disposable Drum
180L
21 884 585 1 PE-HD BCS 56x4 (2x) 1A1/X1,3/250 180L Disposable Drum