Mass Spectrometry AQUA™ Peptides

Developed in collaboration with the Protein Quantitation Consortium, Sigma's AQUA Peptides enable accurate, efficient mass spectrometric quantitation of protein biomarkers. Focus your analysis on significant protein biomarkers Accurately quantitate low abundance proteins Eliminate costly, time consuming stable isotope labeling steps Measure site-specific phosphorylation states Validate gene silencing at the protein level View additional information on the Protein AQUA Strategy and Protein AQUA Applications and Protein AQUA References. This method was developed by Dr. Steve Gygi and colleagues at Harvard Medical School [Stemmann O., Zou H., Gerber S. A., Gygi S. P., Kirschner M. W.; Dual inhibition of sister chromatid separation at metaphase, Cell 2001, Dec 14, 107: 715-726] and is the subject of both U.S. and PCT Patent Applications. Limited use of this method is permitted under a licensing arrangement with Harvard Medical School.

Sigma is pleased to announce the launch of its AQUA Peptide Library. Select from a library of over 300 readily available AQUA Peptides for even greater convenience and value.

Browse The AQUA Peptide Library
Choose from the three methods below:

Download Sequences and Protein IDs
Want associated protein information?

AQUA Library Peptides (Swiss-Prot) (2.19 Mb PDF)

AQUA Library Peptides (NCBI) (1.68 Mb PDF)

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View by Sequence and Product Number
Want to browse the AQUA Peptide Library catalog listings?

View the online catalog of AQUA Library Peptides

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Cannot find your AQUA of interest in the library?
Take advantage of our Custom AQUA Peptide offering.

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Custom AQUA Peptides

To meet the specific demands of AQUA experimentation, Sigma has developed a specialized custom peptide offering. Custom AQUA Peptides are synthesized using fully labeled 98 atom% 13C and 98 atom% 15N enriched amino acids (one labeled amino acid per peptide) and are stringently tested to ensure high purity (HPLC), accurate molecular weight (ESI-MS), and specific peptide content.

To order Custom AQUA Peptides, call 1-800-325-3010 or visit sigma.com/aquaorder.

We invite you, the proteomics community, to contribute to the AQUA Peptide Library through the AQUA Peptide Partnership Program. When you order custom AQUA Peptides, you will be invited to add your sequences to the library. Contributors will receive partnership pricing on their custom orders. The larger proteomics community will enjoy the benefit of accessing the sequences quickly and conveniently in the following months.

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Protein AQUA References

Title	Author / Journal
Full Article Available!: Quantitative, Multiplexed Assays for Low Abundance Proteins in Plasma by Targeted Mass Spectrometry and Stable Isotope Dilution (1.23 Mb PDF)	Hasmik Keshishian, et al. Molecular & Cellular Proteomics October 15, 2007
MOLECULAR AND CELLULAR PROTEOMICS by Madoz-Gúrpide. Copyright 2007 by American Soc for Biochemistry & Molecular Biology. Reproduced with permission of American Soc for Biochemistry & Molecular Biology in the format Internet posting via Copyright Clearance Center.

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