Induced Pluripotent Stem Cell Derived Cardiomyocytes

Sigma^® Life Science is proud to be the global distributor of Axiogenesis murine stem cell derived cell products and drug screening service portfolio. Derived cell types include physiologically relevant cardiomyocytes and smooth muscle cells. Axiogenesis is a leader in mouse pluripotent stem cell derived cardiomyocytes. Together Sigma Life Science and Axiogenesis will provide iPS-cell derived primary-cell-like cardiomyocytes that are more predictive of clinical outcomes for drug discovery and toxicology studies. Cor.At™ cardiomyocytes are extensively characterized and application tested.

Isolation of primary cardiomyocytes are labor intensive and often lack consistency and purity. Sigma Life Science iPSC derived cardiomyocyte products, powered by Axiogenesis, are a consistent and convenient source of large numbers of physiologically relevant cardiomyocytes validated for functional electrophysiology, calcium-flux and calcium-wave analysis, cardiac cytotoxicty, mitochondrial metabolism, and disease model for cardiac hypertrophy.

Cor.At miPSC derived cardiomyocytes are a physiologically relevant model for cardiac toxicity. Derived cell types will be available as off-the-shelf cells, application specific kits and custom services to satisfy the wide range of research needs.

Pure Cor.At cardiomyocytes

Catalog No.	Name
AXIO0044	Cor.At CL-I Cardiomyocytes (Mouse iPS Cell Derived) 1M/vial Kit with Puromycin and Culture Medium
AXIO0045	Cor.At CL-I Cardiomyocytes (Mouse iPS Cell Derived) 5M/vial Kit with Puromycin and Culture Medium
AXIO0046	Cor.At GFP-I Cardiomyocytes (Mouse iPS Cell Derived) 1M/vial Kit with Puromycin and Culture Medium
AXIO0047	Cor.At GFP-I Cardiomyocytes (Mouse iPS Cell Derived) 5M/vial Kit with Puromycin and Culture Medium
AXIO0002	Cor.At CL-I Cardiomyocytes (Mouse iPS Cell Derived) 1M/via
AXIO0006	Cor.At CL-I Cardiomyocytes (Mouse iPS Cell Derived) 5M/vial
AXIO0010	Cor.At GFP-I Cardiomyocytes (Mouse iPS Cell Derived) 1M/vial
AXIO0014	Cor.At GFP-I Cardiomyocytes (Mouse iPS Cell Derived) 5M/vial
AXIO0076	Cor.At Culture Medium

Smooth muscle cells derived from mouse ES Cells available now

Catalog No.	Name
AXIO0053	SMAC.4M TagRFP Smooth Muscle Cells (Mouse ES Cell Derived) 2M/vial Kit with Puromycin and Culture Medium
AXIO0034	SMAC.4M TagRFP Smooth Muscle Cells (Mouse ES Cell Derived) 2M/vial
AXIO0075	SMAC.4M Culture Medium

Custom screening services offered

Cor.At Mel.Cor: Micro Electrode Array (MEA) Analysis using mouse ES derived cardiomyocytes
Cor.4U Mel.Cor: Micro Electrode Array (MEA) Analysis using human iPS derived cardiomyocytes
Cor.At CardioEffect Screening for cardiomyocytes beating pattern (RTCA-Cardio xCELLigence Analysis)
Cor.At Tox Assay for cardiomyocyte-specific cytotoxicity
μEST Assay for embryotoxicity and teratogenicity

To discuss your cardiac toxicity needs or pricing for services please send inquires to scri@sial.com.

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