Stemgent^® Reprogramming Lentiviruses

Induced Pluripotent Stem Cells from Proven Reprogramming Lentiviruses

SIGMA^® Life Science and Stemgent have partnered to bring you proven reprogramming viruses for induced pluripotent stem cell (iPSC) generation. Available in DOX-inducible, non-inducible, and polycistronic formats for both human and mouse, Stemgent reprogramming viruses have been application tested and approved by leaders in the Stem Cell community. All six reprogramming factors are available as individual viruses and functional sets.

Reprogramming for Stem Cell Biology Brochure (2.79 Mb PDF)

Broad assortment of formats and species allows you to reprogram with the lentviruses most appropriate to your specific needs Stringent application testing ensures that lentiviruses have successfully been used to create iPS cells Experienced reprogramming scientists are ready to provide you technical expertise from experimental design through data interpretation, and each step in between Learn more about lentiviruses for mouse cell reprogramming Learn more about lentiviruses for human cell reprogramming

First produced in 2006 from mouse cells and in 2007 from human cells, induced pluripotent stem cells (iPSCs) are recognized by many as a breakthrough development in stem cell biology. IPSCs are created from differntiated cells, often fibroblasts, when they are reprogrammed through the introduction of specific genes. Cells then express these genes and reprogramming is achieved. Once reprogrammed, these new iPSCs resemble their pluripotent embryonic counterparts in many ways including embryoid body formation, teratoma formation, viable chimera formation, doubling, potency, differentiability, chromatin methylation patterns, and protein expression.

Sigma and Stemgent are pleased to support iPSC research by offering Reprogramming Lentiviruses of the highest quality.

Stringent application testing ensures the highest quality of reprogramming lentiviruses.
Two levels of stringent quality control exist for the Stemgent reprogramming lentiviruses:

• Composition Verified: At this level, QC verification has been completed to ensure efficient viral.
• Application Tested: At this level, a published experiment has been reproduced with a production lot of material.

Experienced reprogramming scientists are ready to provide you technical expertise from experimental design through data interpretation, and each step in between. When you contact Sigma’s technical service group, you will be connected to the wealth of reprogramming expertise at Stemgent as well. Scientists at both companies will work with you to find the answers you need to make your reprogramming a success.

Ordering

How to place your order
Orders can be placed either through Sigma or Stemgent, via phone, fax, or website

• Sigma ordering channels
  • Website: www.sigmaaldrich.com
  • Phone (US): 1-800-325-3010; for orders outside the US, contact your local Sigma Customer Service Center
    
• Stemgent ordering channels
  • Website: www.stemgent.com
  • Phone (US): 1-877-228-9783; (International): 1-617-245-0098
  • Fax: 1-858-550-0413

If you order through Stemgent, a Sigma representative will contact you to confirm your order.

How Lentiviruses will Arrive
Whether ordered from Sigma or Stemgent, all Lentivirus orders will be supplied by Sigma. Your order will arrive on dry ice in a Sigma shipping box.

Billing
You will receive an invoice from Sigma for any Reporgramming Lentiviruses that you order. The invoice can be paid just as any other Sigma invoices are paid by your company or institution.

Stemgent advances stem cell science by providing proprietary reagents and tools developed by some of the world's leading stem cell scientists. Stemgent's product offering has been specifically optimized for and screened against stem cells, and includes small molecules for pluripotency, self-renewal, and differentiation, viral-delivered transcription factors, matrices, cell lines, cytokines, antibodies, transfection reagents, and more. This unique product mix is designed to serve researchers who study stem cell biology and regenerative medicine, and those who use cells derived from stem cells as tools to advance their understanding of major diseases.

Sigma-Aldrich has been a leading Life Science and High Technology company since 1945. Through SIGMA Life Science we have developed tools enabling researchers to accelerate discovery across the entire drug development research workflow including RNAi and sample prep platforms. For stem cell research, Sigma offers a comprehensive and unprecedented number of products to support scientists in the discovery efforts to better understand the cellular processes controlling development, aging, disease and tissue regeneration. Our product offering includes media, antibodies, 3D matrices, growth factors, small molecules, RNAi, and Zinc Finger Nuclease Technology.

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