Find Sox 14 Products
Gene SOX14: SOX 14_HUMAN
Transcription factor SOX-14
NCBI/Entrez	8403
HGNC	11193
UniProt/Swiss-Prot/ UniProt/TrEMBL	O95416, O95132, Q3KPH7
Ensembl	ENSG00000168875
OMIM	604747
GeneCards	GC03P138966
Synonyms: MGC119898, MGC119899, SOX28, SRY-box 14, Transcription factor SOX-14

SRY (sex determining region Y)-box 14/Sox-14 (Gene SOX14) Homo sapiens

The SOX14 (map locus: Entrez and HGNC: 3q22-q23; Ensembl: 3q22.3, Malas S, et al. (1999)) gene product, SRY (sex determining region Y)-box 14/Sox-14 protein, is a 240 AA (26.5 kDa) high mobility group (HMG box) domain (8 to 76) containing transcription factor. HMG box domains preferentially bind to and distort DNA.

The Sox family members are HMG-box containing transcription factors related to mammalian testis determining factor, SRY. Sox14 and Sox21 are B2-subgroup Sox transcription factors involved primarily in gene repression, especially of neurogenesis. Sox14 and Sox21 are similar to one another but distinct from the B1-subgroup Sox proteins, Sox1, Sox2 and Sox3. Sox14 and Sox21 are viewed as opposing regulators of genes regulated by the B1 Sox factors, Uchikawa M et al. (1999).

Sox14 is expressed in fetal brain, spinal cord, thymus, Arsic N, et al. (1998), specific brain nuclei of the dorsal thalamus (DT), Hashimoto-Torii K, et al. (2003), and the ventromedial hypothalamus (VHM), Kurrasch DM et al. (2007). It is the only Sox gene that has been shown to express in the apical ectodermal ridge (AER) of limb buds, Wilmore HP, et al. (2000). Sox14 is believed to function in dorsoventral cell-type specification in the spinal cord, Hargrave M, et al. (2000). It marks a subset of interneurons at a defined dorsoventral position adjacent to ventral motor neurons in the spinal cord.

The Sox14 gene promoter contains binding sites for the transcription factors NF-Y, Sp1 and USF1, Djurovic J and Stevanovic M (2004), Kovacevic-Grujicic N, et al. (2008).

Sigma offers antibodies, shRNAs and other products useful for the study of the SOX 14 gene.

References:

Arsic N, et al. (1998) Characterisation and mapping of the human SOX14 gene. Cytogenet Cell Genet. 83: 139-146.

Djurovic J and Stevanovic M. (2004) Structural and functional characterization of the human SOX14 promoter. Biochim Biophys Acta. 1680: 53-59.

Hargrave M, et al. (2000) The HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog. Dev Biol. 219: 142-153.

Hashimoto-Torii K, et al. (2003) Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus. Mech Dev. 120: 1097-1111.

Kovacevic-Grujicic N, et al. (2008) Comparison of promoter regions of SOX3, SOX14 and SOX18 orthologs in mammals. DNA Seq. 19: 185-194..

Kurrasch DM, et al. (2007) The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. J Neurosci. 27: 13624-13634.

Malas S, et al. (1999) The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3. Mamm Genome. 10: 934-937.

Uchikawa M, et al. (1999) Two distinct subgroups of Group B Sox genes for transcriptional activators and repressors: their expression during embryonic organogenesis of the chicken. Mech Dev. 84: 103-1020.

Wilmore HP, et al. (2000) SOX14 is a candidate gene for limb defects associated with BPES and Möbius syndrome. Hum Genet. 106: 269-276.

Footnote: Gene Data Sources: HGNC, Entrez Gene, UniProt/Swiss-Prot, UniProt/TrEMBL, GDB, OMIM, GeneLoc, Ensembl.