Find ADRB1 Products Interaction Network for ADRB1 ADRB1 Details

Related Pathways Cardiac beta-adrenergic Signaling cAMP-mediated Signaling G-Protein Coupled Receptor Signaling View All Pathways

Synonyms: ADRB1, ADRB1R, Adrenergic Receptor Beta 1, B1AR, BETA-AR, BETA1 ADRENERGIC RECEPTOR, BETA1-ADRENORECEPTOR, BETA1AR, RATB1AR, RHR

beta-Adrenergic Signaling Pathway

The catecholamines epinephrine (adrenaline) and norepinephrine (noradrenaline) are agonists for a family of G-protein coupled receptors (GPCRs) known as adrenergic receptors. There are three subfamilies of adrenergic receptors: alpha1 (a1), alpha2 (a2) and beta (b). The beta subfamily contains three subtypes: b1 (b1AR), b2 (b2AR), and b3 (b3AR) located predominantly in heart, lung and adipose tissue respectively.

Adrenergic receptors are GPCRs that link to trimeric G-protein. G-proteins are typically composed of alpha, beta and gamma subunits. Each subunit exists in multiple isotypes with differential specificity for effector signaling. Specificity of response to catecholamines is mediated in part by the Galpha subunits, but the Gbetagamma dimers are also involved in regulation. Beta adrenergic receptors favor interaction with heterotrimeric G-proteins that contain the Galphas (Gs) and Galphai (Gi) subunit. The Galphas subunits activate various isoforms of adenylate (adenylyl) cyclases. Consequently b-adrenergic receptors typically elevate the level of cyclic AMP (cAMP) an important mediator of cell signaling. Both Galphas and Galphai have been linked to the stimulation of Src family tyrosine kinases. Galphas and Gbetagamma (dimeric) subunits regulate L-type Ca²⁺ channels. Beta adrenergic receptors also interact with other G-protein Galpha isotypes to provide additional specificity to agonist binding within cell context. Beta adrenergic receptors of different isotypes use combinations of G-proteins subunits to integrate specific cellular pathways and responses.